Drug Selection for Intrathecal Drug Delivery

Karina Gritsenko; Veronica Carullo; Timothy R. Deer; Jason E. Pope

doi:10.1007/978-1-4939-2110-2_41

Drug Selection for Intrathecal Drug Delivery

Karina Gritsenko, Veronica Carullo, Timothy R. Deer, Jason E. Pope

Anesthesiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

The use of intrathecal agents to treat pain and other diseases, such as spasticity, is based on the principle that delivering drugs directly to the cerebral spinal fluid (CSF) bypasses the first-pass effect and results in increased potency and reduced systemic side-effects as compared to other routes of delivery such as the oral or transdermal approach. This may improve efficacy and sustainability, as compared to epidural, intravenous, oral, or transdermal preparations.

Original language	English (US)
Title of host publication	Atlas of Implantable Therapies for Pain Management
Subtitle of host publication	Second Edition
Publisher	Springer New York
Pages	287-291
Number of pages	5
ISBN (Electronic)	9781493921102
ISBN (Print)	9781493921096
DOIs	https://doi.org/10.1007/978-1-4939-2110-2_41
State	Published - Jan 1 2015

Keywords

Guidelines
Intrathecal drug delivery
Intrathecal medication
Selection
Targeted drug delivery

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4939-2110-2_41

Cite this

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AU - Carullo, Veronica

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AU - Pope, Jason E.

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AB - The use of intrathecal agents to treat pain and other diseases, such as spasticity, is based on the principle that delivering drugs directly to the cerebral spinal fluid (CSF) bypasses the first-pass effect and results in increased potency and reduced systemic side-effects as compared to other routes of delivery such as the oral or transdermal approach. This may improve efficacy and sustainability, as compared to epidural, intravenous, oral, or transdermal preparations.

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KW - Selection

KW - Targeted drug delivery

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ER -

Drug Selection for Intrathecal Drug Delivery

Abstract

Keywords

ASJC Scopus subject areas

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