Down Syndrome and Thyroid Function

Evan Graber; Elizabeth Chacko; Molly O. Regelmann; Gertrude Costin; Robert Rapaport

doi:10.1016/j.ecl.2012.08.008

Down Syndrome and Thyroid Function

Evan Graber, Elizabeth Chacko, Molly O. Regelmann, Gertrude Costin, Robert Rapaport

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.

Original language	English (US)
Pages (from-to)	735-745
Number of pages	11
Journal	Endocrinology and Metabolism Clinics of North America
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.ecl.2012.08.008
State	Published - Dec 1 2012
Externally published	Yes

Keywords

Down syndrome
Euthyroidism
Hypothyroidism
Thyroid function

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ecl.2012.08.008

Cite this

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title = "Down Syndrome and Thyroid Function",

abstract = "Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.",

keywords = "Down syndrome, Euthyroidism, Hypothyroidism, Thyroid function",

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AU - Graber, Evan

AU - Chacko, Elizabeth

AU - Regelmann, Molly O.

AU - Costin, Gertrude

AU - Rapaport, Robert

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.

AB - Thyroid dysfunction in children with Down syndrome (DS) can occur as early as birth. As children with DS age, their risk for thyroid autoimmunity manifested as autoimmune hypothyroidism or Graves disease increases. The optimal timing and method for thyroid screening in children with DS remains controversial. The American Academy of Pediatrics recommends annual screening in this population. Consensus is needed to establish working definitions of euthyroidism and mild hypothyroidism in all infants, but especially in those with DS.

KW - Down syndrome

KW - Euthyroidism

KW - Hypothyroidism

KW - Thyroid function

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SN - 0889-8529

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JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

IS - 4

ER -

Down Syndrome and Thyroid Function

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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