Does COMT val158met affect behavioral phenotypes: Yes, no, maybe?

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations


The COMT gene functional polymorphism val158met is one of the most intensively studied variants in psychiatric genetics. Due to small effect size and various methodological issues, its role in various psychiatric disorders and behavioral traits has still not been unequivocally established. In this issue of Neuropsychopharmacology, several studies are presented supporting a role for COMT as a factor in cocaine addiction, brain reward activation, response to tolcapone, distractibility in ADHD, and fMRI bold response. The studies make important contributions to the growing literature that aim to establish an effect of this functional variant on behavioral phenotypes and treatment response.

Original languageEnglish (US)
Pages (from-to)3027-3029
Number of pages3
Issue number13
StatePublished - Dec 2008


  • Behavioral genetics
  • COMT
  • Catechol-O-methyltransferase
  • Psychiatric genetics

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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