Do the longevity genes prevent dementia?

Research output: Contribution to journalArticlepeer-review


The identification of genetic risk factors for the familial dementias has been a productive area of scientific study, but the clinical impact for the far more common sporadic dementias has been modest at best. As a result, interest in the characterization of biomedical and psychosocial protective factors is intense as evidenced by the April 2010 National Institutes of Health (NIH) consensus conference on Preventing Alzheimer's Disease and Cognitive Decline. If genetic polymorphisms associated with exceptional longevity are associated with lessened incidence of dementia, their characterization may suggest novel pharmacologic interventions to prevent Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)20-22
Number of pages3
JournalPrimary Psychiatry
Issue number3
StatePublished - Mar 2010

ASJC Scopus subject areas

  • Psychiatry and Mental health


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