Do Acid-Lowering Agents Affect Vitamin B12 Status in Older Adults?

T. S. Dharmarajan, Madhusudhana R. Kanagala, Padmavathi Murakonda, Ahna S. Lebelt, Edward P. Norkus

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Objective: To examine the relationship between serum vitamin B12 levels in older adults on histamine2 receptor antagonists (H2 blockers) or proton-pump inhibitors (PPI) over 6 years. Participants: A cross-sectional sample of 659 adults, 60 to 102 years, from long-term care facilities and community ambulatory care (C) in the Bronx. Measurements: Patient demographics, serum B12 levels, use and duration of use of H2 blockers, PPIs, antacids, multivitamin/minerals, liquid dietary supplements, oral vitamin B12 supplementation, oral or intramuscular B12 therapy, and recent lab chemistries. Results: Acid-lowering agents (ALA) were used by 54% (PPIs by 26% and H2 blockers by 28%), duration averaged 18.2 ± 16.0 (SD) months. NH and C subjects had similar ages (P = .9971), gender distributions (P = .625), durations of ALA use (P = .1227), and rates of PPI use (P = .130); NH subjects used more H2 blockers (P < .0005) and had less low B12 status (P = .037). H2 blocker use did not influence serum B12 status (P = .1036) while PPI use was associated with diminished serum B12 levels (P < .00005). Concomitant oral B12 supplementation slowed but did not prevent the decline in B12 status during prolonged PPI use (P = .0125). Conclusions: B12 status declines during prolonged PPI use in older adults, but not with prolonged H2 blocker use; supplementation with RDA amounts of B12 do not prevent this decline. This report reinforces that B12 deficiency is common in the elderly and suggests that it appears prudent to monitor periodically B12 status while on prolonged PPI use, to enable correction before complications ensue.

Original languageEnglish (US)
Pages (from-to)162-167
Number of pages6
JournalJournal of the American Medical Directors Association
Issue number3
StatePublished - Mar 2008


  • Vitamin B12 status
  • acid-lowering agents
  • histamine receptor blockers and B12 status
  • proton-pump inhibitors and B12 levels

ASJC Scopus subject areas

  • Nursing(all)
  • Health Policy
  • Geriatrics and Gerontology


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