@article{75a12453279d425eb475cd2d3834cb8d,
title = "DNA replication in synchronized cultured mammalian cells. V. The temporal order of synthesis of component α DNA during monkey DNA synthesis induced by SV40 virus",
abstract = "Purified simian virus 40 (SV40) was used to induce host DNA replication in contact-inhibited monolayer cultures of African green monkey kidney cells. Approximately 20% of the nuclear DNA of these cells is the simple sequence, component α DNA (Maio, 1971). At the beginning of DNA synthesis induced by SV40 viral infection, the average ratio of the specific radioactivity of component α DNA to that of bulk DNA was 0.18. Similar low specific activity ratios are observed early during the DNA synthetic period following the trypsin release of monkey cells from contact inhibition. These results indicate that when host DNA replication is induced by SV40 viral infection, component α DNA synthesis does not shift to precede the replication of bulk DNA.",
author = "Parker, {Robert J.} and Tobia, {Annette M.} and Baum, {Stephen G.} and Schildkraut, {Carl L.}",
note = "Funding Information: We are grateful to Dr. I. Balazs, Dr. M. Botchan, Dr. A. Levine, and Dr. J. Maio for helpful advice and Mr. E. Brown and Mr. T. Greenzang for their assistance. This study was supported by the Damon Runyon Memorial Fund (No. DRG-1275), the National Science Foundation (No. GB 33691X2) and the National Institutes of Health (No. CA 10945-07). R. J. Funding Information: Parker was supported by a postdoctoral fellowship from the National Institutes of Health (No. 6 F02 GM52484-02). S. G. Baum is a Faculty Research Awardee of the American Cancer Society.",
year = "1975",
month = jul,
doi = "10.1016/0042-6822(75)90180-4",
language = "English (US)",
volume = "66",
pages = "82--93",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",
}