TY - JOUR
T1 - Diversification of CD1 proteins
T2 - Sampling the lipid content of different cellular compartments
AU - Briken, Volker
AU - Moody, D. Branch
AU - Porcelli, Steven A.
N1 - Funding Information:
ported by a fellowship from ‘Human Frontier Science Program Organization’. D. B. Moody is supported by a grant from ‘American College of Rheumatology Research and Education Foundation’ and NIH/NIAMS. S. A. Porcelli is supported by grants from the NIH/NIAID.
PY - 2000
Y1 - 2000
N2 - Four human CD1 isoforms (CD1a, -b,-c and -d) are now known to be antigen presenting molecules with the unique ability to present lipid antigens to T cells. CD1b and CD1d are found in acidic, late endocytic compartments, whereas CD1a and CD1c molecules accumulate at the plasma membrane and in early endosomes. Consistent with their differences in intracellular localization, most studies show antigen presentation by CD1b/CD1d to be dependent on endosomal acidification while CD1a/CD1c mediated antigen presentation is not. Taken together, recent advances in the analysis of CD1 molecules reinforce the hypothesis that the different CD1 isoforms are specialized to survey the lipid content of distinct intracellular compartments. This may help to explain the duplication and diversification of CD1 genes in humans and other mammalian species.
AB - Four human CD1 isoforms (CD1a, -b,-c and -d) are now known to be antigen presenting molecules with the unique ability to present lipid antigens to T cells. CD1b and CD1d are found in acidic, late endocytic compartments, whereas CD1a and CD1c molecules accumulate at the plasma membrane and in early endosomes. Consistent with their differences in intracellular localization, most studies show antigen presentation by CD1b/CD1d to be dependent on endosomal acidification while CD1a/CD1c mediated antigen presentation is not. Taken together, recent advances in the analysis of CD1 molecules reinforce the hypothesis that the different CD1 isoforms are specialized to survey the lipid content of distinct intracellular compartments. This may help to explain the duplication and diversification of CD1 genes in humans and other mammalian species.
KW - Antigen presentation
KW - CD1
KW - Intracellular transport
KW - Lipids
KW - Mycobacterium tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=0034527890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034527890&partnerID=8YFLogxK
U2 - 10.1006/smim.2000.0274
DO - 10.1006/smim.2000.0274
M3 - Article
C2 - 11145857
AN - SCOPUS:0034527890
SN - 1044-5323
VL - 12
SP - 517
EP - 525
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 6
ER -