Distinct Regions of Allelic Loss on Chromosome 4 in Human Primary Bladder Carcinoma

Thomas J. Polascik, Wayne Y.H. Chang, Mark P. Schoenberg, Wayne Y.H. Chang, Paul Cairns, David Sidransky

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


Accumulating evidence implicates the presence of putative tumor suppressor genes on human chromosome 4 that are potentially inactivated in the genesis of several different neoplasms. To accurately determine the frequency of allelic loss on both arms of human chromosome 4, we screened 282 fresh-frozen human bladder carcinomas for allelic loss. Loss of heterozygosity of at least one marker for chromosome 4 was identified in 129 tumors (45.7%). Fine mapping was accomplished using up to 15 polymorphic markers on the p arm and 19 markers on the q arm. We identified a 3-cM minimal area of loss on the p arm between microsatellite markers D4S1608 and D4S404 deleted in 82 tumors (29%). A total of 68 tumors (24%) targeted a 14-cM critical region identified on the distal q arm between markers D4S426 and D4S408. Loss of these two regions correlated with advanced stage and grade of the lesions. These data identify distinct regions of loss on chromosome 4 potentially involved in the late progression of bladder carcinoma.

Original languageEnglish (US)
Pages (from-to)5396-5399
Number of pages4
JournalCancer research
Issue number22
StatePublished - Nov 15 1995
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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