Distinct light microscopic changes in human immunodeficiency virus- associated nemaline myopathy

Daniel M. Feinberg; Alfred J. Spiro; Karen M. Weidenheim

doi:10.1212/WNL.50.2.529

Distinct light microscopic changes in human immunodeficiency virus- associated nemaline myopathy

Daniel M. Feinberg, Alfred J. Spiro, Karen M. Weidenheim

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.

Original language	English (US)
Pages (from-to)	529-531
Number of pages	3
Journal	Neurology
Volume	50
Issue number	2
DOIs	https://doi.org/10.1212/WNL.50.2.529
State	Published - Feb 1998
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1212/WNL.50.2.529

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title = "Distinct light microscopic changes in human immunodeficiency virus- associated nemaline myopathy",

abstract = "The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.",

author = "Feinberg, {Daniel M.} and Spiro, {Alfred J.} and Weidenheim, {Karen M.}",

year = "1998",

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AU - Feinberg, Daniel M.

AU - Spiro, Alfred J.

AU - Weidenheim, Karen M.

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N2 - The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.

AB - The purpose of this study was to compare histologic characteristics of congenital nemaline myopathy (CNM), adult-onset nemaline myopathy (AONM), and human immunodeficiency virus-associated adult-onset nemaline myopathy (HAONM). There was no difference between the pathology of CNM and AONM; however, HAONM had distinctive pathologic features by light microscopy. The fibers in HAONM showed marked intrasarcoplasmic changes, including small vacuoles and granular degeneration.

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Distinct light microscopic changes in human immunodeficiency virus- associated nemaline myopathy

Abstract

ASJC Scopus subject areas

UN SDGs

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