TY - JOUR
T1 - Disparities in outcomes between Black and White patients in North America with thoracic malignancies and COVID-19 infection (TERAVOLT)
AU - Burns, Laura
AU - Hsu, Chih Yuan
AU - Whisenant, Jennifer G.
AU - Marmarelis, Melina E.
AU - Presley, Carolyn J.
AU - Reckamp, Karen L.
AU - Khan, Hina
AU - Jo Fidler, Mary
AU - Bestvina, Christine M.
AU - Brahmer, Julie
AU - Puri, Sonam
AU - Patel, Jyoti D.
AU - Halmos, Balazs
AU - Hirsch, Fred R.
AU - Liu, Stephen V.
AU - Costa, Daniel B.
AU - Goldberg, Sarah B.
AU - Feldman, Lawrence E.
AU - Mamdani, Hirva
AU - Puc, Matthew
AU - Mansfield, Aaron S.
AU - Islam, Nahida
AU - Scilla, Katherine A.
AU - Garassino, Marina C.
AU - Horn, Leora
AU - Peters, Solange
AU - Wakelee, Heather A.
AU - Charlot, Marjory
AU - Tapan, Umit
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/12
Y1 - 2023/12
N2 - Background: Patients with thoracic malignancies who develop COVID-19 infection have a higher hospitalization rate compared to the general population and to those with other cancer types, but how this outcome differs by race and ethnicity is relatively understudied. Methods: The TERAVOLT database is an international, multi-center repository of cross-sectional and longitudinal data studying the impact of COVID-19 on individuals with thoracic malignancies. Patients from North America with thoracic malignancies and confirmed COVID-19 infection were included for this analysis of racial and ethnic disparities. Patients with missing race data or races and ethnicities with fewer than 50 patients were excluded from analysis. Multivariable analyses for endpoints of hospitalization and death were performed on these 471 patients. Results: Of the 471 patients, 73% were White and 27% were Black. The majority (90%) were non-Hispanic ethnicity, 5% were Hispanic, and 4% were missing ethnicity data. Black patients were more likely to have an Eastern Cooperative Oncology Group (ECOG) Performance Status ≥ 2 (p-value = 0.04). On multivariable analysis, Black patients were more likely than White patients to require hospitalization (Odds Ratio (OR): 1.69, 95% CI: 1.01–2.83, p-value = 0.044). These differences remained across different waves of the pandemic. However, no statistically significant difference in mortality was found between Black and White patients (OR 1.29, 95% CI: 0.69–2.40, p-value = 0.408). Conclusions: Black patients with thoracic malignancies who acquire COVID-19 infection are at a significantly higher risk of hospitalization compared to White patients, but there is no significant difference in mortality. The underlying drivers of racial disparity among patients with thoracic malignancies and COVID-19 infection require ongoing investigation.
AB - Background: Patients with thoracic malignancies who develop COVID-19 infection have a higher hospitalization rate compared to the general population and to those with other cancer types, but how this outcome differs by race and ethnicity is relatively understudied. Methods: The TERAVOLT database is an international, multi-center repository of cross-sectional and longitudinal data studying the impact of COVID-19 on individuals with thoracic malignancies. Patients from North America with thoracic malignancies and confirmed COVID-19 infection were included for this analysis of racial and ethnic disparities. Patients with missing race data or races and ethnicities with fewer than 50 patients were excluded from analysis. Multivariable analyses for endpoints of hospitalization and death were performed on these 471 patients. Results: Of the 471 patients, 73% were White and 27% were Black. The majority (90%) were non-Hispanic ethnicity, 5% were Hispanic, and 4% were missing ethnicity data. Black patients were more likely to have an Eastern Cooperative Oncology Group (ECOG) Performance Status ≥ 2 (p-value = 0.04). On multivariable analysis, Black patients were more likely than White patients to require hospitalization (Odds Ratio (OR): 1.69, 95% CI: 1.01–2.83, p-value = 0.044). These differences remained across different waves of the pandemic. However, no statistically significant difference in mortality was found between Black and White patients (OR 1.29, 95% CI: 0.69–2.40, p-value = 0.408). Conclusions: Black patients with thoracic malignancies who acquire COVID-19 infection are at a significantly higher risk of hospitalization compared to White patients, but there is no significant difference in mortality. The underlying drivers of racial disparity among patients with thoracic malignancies and COVID-19 infection require ongoing investigation.
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U2 - 10.1016/j.lungcan.2023.107423
DO - 10.1016/j.lungcan.2023.107423
M3 - Article
C2 - 37995456
AN - SCOPUS:85177843584
SN - 0169-5002
VL - 186
JO - Lung Cancer
JF - Lung Cancer
M1 - 107423
ER -