Discrepancies in vessel sizing between angiography and intravascular ultrasound varies according to the vessel evaluated

Kensuke Takagi, Joanne Shannon, Sandeep Basavarajaiah, Azeem Latib, Rasha Al-Lamee, Tasuku Hasegawa, Cosmo Godino, Massimo Ferraro, Filippo Figini, Mauro Carlino, Matteo Montorfano, Alaide Chieffo, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background/objectives Quantitative coronary analysis (QCA) of the coronary artery and stent size may be influenced by anatomical location in relation to both calibration point and the X-ray tube. The impact of this phenomenon on lesion assessment is undetermined. Methods In total, 427 consecutive patients who underwent PCI with intravascular ultrasound (IVUS)-guidance were enrolled. The minimum stent diameter (MSD) was measured using QCA (MSDQCA) and IVUS (MSDIVUS) analysis. We used reference objects positioned at a different height from the X-ray source to validate our approach. Results A statistically positive moderate correlation was observed between MSD QCA and MSDIVUS (r = 0.649, p = 0.001). The mean MSD QCA and MSDIVUS were 3.04 ± 0.49 mm and 2.68 ± 0.47 mm respectively. The difference between MSDQCA and MSDIVUS of > 0.75 mm was more frequently observed in the LCx rather than in the LAD (7.4% in the LAD vs. 24.3% in the LCx, p = 0.001). The discrepancy between the MSDQCA and MSDIVUS for the LCx was larger than for the LAD, and tended to be larger than for the RCA (13.3% vs. 18.5%, p = 0.05 and 18.5% vs. 14.5%, p = 0.17). A discrepancy > 20% was more frequently observed in the small (≤ 2.5 mm) than in the large MSD IVUS group (52.7% vs. 25.1%, p = 0.001). This discrepancy was more common in the LCx than in the LAD or RCA (48.6% vs. 30.9% vs. 31.2%, p = 0.03). Conclusions Assessment of the MSDQCA is more likely to overestimate in the LCx than in the LAD, particularly when the MSDIVUS is < 2.5 mm. Therefore, we should be less aggressive in oversizing balloons and stents based on QCA for the LCx or small vessel intervention.

Original languageEnglish (US)
Pages (from-to)3791-3796
Number of pages6
JournalInternational Journal of Cardiology
Issue number4
StatePublished - Oct 9 2013
Externally publishedYes


  • Angiography
  • Discrepancy
  • Intravascular imaging
  • Lesion location
  • MSD

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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