Dips in dopamine say “no” to nicotine

Alice Servonnet, Saleem M. Nicola

Research output: Contribution to journalComment/debatepeer-review


Nicotine has both rewarding and aversive effects. In this issue of Neuron, Liu et al. show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nAChRs) that activate midbrain dopamine neurons and activation of low-affinity nAChRs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (LDT).

Original languageEnglish (US)
Pages (from-to)2895-2898
Number of pages4
Issue number18
StatePublished - Sep 21 2022

ASJC Scopus subject areas

  • Neuroscience(all)


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