Abstract
The response to mitogens of peripheral blood lymphocytes (PBL) from adenosine deaminase deficient (ADA-) patients with Severe Combined Immunodeficiency (SCID), but not from normals, was more sensitive to inhibition by deoxyadenosine than by adenosine. In contrast, proliferation of long-term lymphoid line (B) cells from these patients was essentially equally inhibited by adenosine and deoxyadenosine. Deoxycytidine could "rescue" ADA- PBLs from deoxyadenosine toxicity.
Original language | English (US) |
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Pages (from-to) | 418-423 |
Number of pages | 6 |
Journal | Cellular Immunology |
Volume | 42 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1979 |
ASJC Scopus subject areas
- Immunology