Differential effects of interleukin-4 in peptide induced autoimmunity

Bisram Deocharan, Paola Marambio, Morris Edelman, Chaim Putterman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


BALB/c mice immunized with multimeric DWEYSVWLSN develop IgG1 anti-DNA antibodies and glomerular immunoglobulin deposits, leading us to investigate the role of IL-4 in this model of antigen induced lupus. Splenocytes from DWEYSVWLSN immunized mice secreted IL-4 but not γ-interferon. Following peptide immunization, IgG1 anti-peptide and anti-DNA antibodies were significantly higher in IL-4 wild type mice, while IgM and IgG3 anti-DNA levels were significantly higher in IL-4 knockout mice. Titers of IgG anti-laminin and anti-histone, but not anti-Sm/RNP and anti-cardiolipin antibodies, were significantly higher in the IL-4 wild type group. Glomerular immunoglobulin deposition was substantially decreased in IL-4 knockout mice. We conclude that while IL-4 does not materially affect the generation of some autoantibody responses associated with peptide induced autoimmunity, IL-4 deficiency inhibits kidney immunoglobulin deposition. The effect of IL-4 on humoral autoimmunity in lupus is complex, and is dependent on genetic background, the antigenic trigger and stage of disease.

Original languageEnglish (US)
Pages (from-to)80-88
Number of pages9
JournalClinical Immunology
Issue number2
StatePublished - Aug 1 2003
Externally publishedYes


  • Anti-DNA antibodies
  • Autoantibodies
  • Cytokines
  • Glomerulonephritis
  • Interleukin-4
  • Peptide mimetope
  • SLE

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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