Abstract
In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4-CD8- (double-negative) T cells and CD8+ T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4-CD8- T cells was mediated by Fas-FasL interaction and had no effect on the viability of the mycobacteria. The CD8+ T cells lysed infected macrophages by a Fas-independent, granule-dependent mechanism that resulted in killing of bacteria. These data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.
Original language | English (US) |
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Pages (from-to) | 1684-1687 |
Number of pages | 4 |
Journal | Science |
Volume | 276 |
Issue number | 5319 |
DOIs | |
State | Published - Jun 13 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- General