Different effects of methionine-enkephalin on paw edema in two inbred rat strains

Stanislava Stanojevi; Jelena Radulovi; Vesna Kovacevi-Jovanovi; Vesna Vuji; Mirjana Dimitrijevi

doi:10.1016/S0196-9781(02)00105-5

Different effects of methionine-enkephalin on paw edema in two inbred rat strains

Stanislava Stanojevi, Jelena Radulovi, Vesna Kovacevi-Jovanovi, Vesna Vuji, Mirjana Dimitrijevi

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (δ opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (κ opioid receptors antagonist) and β-funaltrexamine (μ opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.

Original language	English (US)
Pages (from-to)	1597-1605
Number of pages	9
Journal	Peptides
Volume	23
Issue number	9
DOIs	https://doi.org/10.1016/S0196-9781(02)00105-5
State	Published - Sep 2002
Externally published	Yes

Keywords

Concanavalin A
Methionine-enkephalin
Naloxone
Naltrindole
Paw edema
Rat strain
nor-Binaltorphimine
β-Funaltrexamine
δ, κ, μ Opioid receptors

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Access to Document

10.1016/S0196-9781(02)00105-5

Cite this

@article{f5ee7fa70e5c43d6aadee563aac1d487,

title = "Different effects of methionine-enkephalin on paw edema in two inbred rat strains",

abstract = "The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (δ opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (κ opioid receptors antagonist) and β-funaltrexamine (μ opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.",

keywords = "Concanavalin A, Methionine-enkephalin, Naloxone, Naltrindole, Paw edema, Rat strain, nor-Binaltorphimine, β-Funaltrexamine, δ, κ, μ Opioid receptors",

author = "Stanislava Stanojevi and Jelena Radulovi and Vesna Kovacevi-Jovanovi and Vesna Vuji and Mirjana Dimitrijevi",

note = "Funding Information: The technical assistance of Mrs. Zuzana Toma{\v s} is gratefully acknowledged. This work was supported by the Ministry of Science, Technology and Development, Republic of Serbia, Belgrade, Yugoslavia.",

year = "2002",

month = sep,

doi = "10.1016/S0196-9781(02)00105-5",

language = "English (US)",

volume = "23",

pages = "1597--1605",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "9",

}

TY - JOUR

T1 - Different effects of methionine-enkephalin on paw edema in two inbred rat strains

AU - Stanojevi, Stanislava

AU - Radulovi, Jelena

AU - Kovacevi-Jovanovi, Vesna

AU - Vuji, Vesna

AU - Dimitrijevi, Mirjana

N1 - Funding Information: The technical assistance of Mrs. Zuzana Tomaš is gratefully acknowledged. This work was supported by the Ministry of Science, Technology and Development, Republic of Serbia, Belgrade, Yugoslavia.

PY - 2002/9

Y1 - 2002/9

N2 - The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (δ opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (κ opioid receptors antagonist) and β-funaltrexamine (μ opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.

AB - The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (δ opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (κ opioid receptors antagonist) and β-funaltrexamine (μ opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.

KW - Concanavalin A

KW - Methionine-enkephalin

KW - Naloxone

KW - Naltrindole

KW - Paw edema

KW - Rat strain

KW - nor-Binaltorphimine

KW - β-Funaltrexamine

KW - δ, κ, μ Opioid receptors

UR - http://www.scopus.com/inward/record.url?scp=0036710536&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036710536&partnerID=8YFLogxK

U2 - 10.1016/S0196-9781(02)00105-5

DO - 10.1016/S0196-9781(02)00105-5

M3 - Article

C2 - 12217420

AN - SCOPUS:0036710536

SN - 0196-9781

VL - 23

SP - 1597

EP - 1605

JO - Peptides

JF - Peptides

IS - 9

ER -

Different effects of methionine-enkephalin on paw edema in two inbred rat strains

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this