Different effects of methionine-enkephalin on paw edema in two inbred rat strains

Stanislava Stanojevi, Jelena Radulovi, Vesna Kovacevi-Jovanovi, Vesna Vuji, Mirjana Dimitrijevi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The effect of intraplantarly (i.pl.)-injected methionine-enkephalin (ME) on Concanavalin A (Con A)-induced paw edema in Dark Agouti (DA) and Albino Oxford (AO) rats was investigated. ME suppressed edema in DA rats, which was antagonized with naloxone (non-selective opioid receptor antagonist) and naltrindole (δ opioid receptors antagonist). Potentiating effect of ME in AO rats was blocked by naloxone, nor-binaltorphimine (κ opioid receptors antagonist) and β-funaltrexamine (μ opioid receptors antagonist). Dexamethasone suppressed edema in both rat strains. These findings suggest that strain-dependent differences in the effects of ME on inflammation in DA and AO rats could be related to diversity in opioid receptors expression in these strains.

Original languageEnglish (US)
Pages (from-to)1597-1605
Number of pages9
Issue number9
StatePublished - Sep 2002
Externally publishedYes


  • Concanavalin A
  • Methionine-enkephalin
  • Naloxone
  • Naltrindole
  • Paw edema
  • Rat strain
  • nor-Binaltorphimine
  • β-Funaltrexamine
  • δ, κ, μ Opioid receptors

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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