Dietary vitamin c and uterine cervical dysplasia

Sylvia Wassertheil-smoller, Seymour L. Romney, Judith Wylie-rosett, Susan Slagle, Gail Miller, David Lucido, Chandralekha Duttagupta, Prabhudas R. Palan

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


A case-control study of women with cervical abnormalities identified through Pap smears, was conducted in the Bronx, New York, to explore the relationship between nutritional intake and cervical dysplasia. Nutrient intake was estimated from computer analysis of three-day food records and 24-hour recall for 169 study participants (87 cases, 82 controls), including a subset of 49 pairs matched for age, race and parity. Mean vitamin C intake per day from three-day food record for controls was 107 mg, compared to 80mg for cases (p <0.01). Analysis of matched pairs showed similar results; 29% of cases compared to 3% of controls in matched subset had vitamin C intake less than 50% of the recommended daily allowance, yielding a ten-fold increase in risk of cervical dysplasia as estimated by odds ratio (p <0.05). Younger age, greater frequency of sexual intercourse and younger age at first intercourse were associated with higher risk of cervical dysplasia. Multiple logistic analyses indicated that low vitamin C intake is an independent contributor to risk of severe cervical dysplasia when age and sexual activity variables are controlled. Approximately 35% of US women in their reproductive years have daily vitamin C intake below 30 mg, and 68% have vitamin C intake below 88 mg. If other studies confirm these findings, it may be important to explore a possibie protective role of supplementary vitamin C for women at high risk of cervical cancer.

Original languageEnglish (US)
Pages (from-to)714-724
Number of pages11
JournalAmerican Journal of Epidemiology
Issue number5
StatePublished - Nov 1981


  • Cervical neoplasms
  • Neopiasms
  • Nutrition
  • Vitamin C

ASJC Scopus subject areas

  • Epidemiology


Dive into the research topics of 'Dietary vitamin c and uterine cervical dysplasia'. Together they form a unique fingerprint.

Cite this