Dietary factors and risk of breast cancer: Combined analysis of 12 case - control studies

Geoffrey R. Howe, Tomio Hirohata, T. Gregory Hislop, Jose Mario Iscovich, Jian Min Yuan, Klea Katsouyanni, Flora Lubin, Ettore Marubini, Baruch Modan, Thomas Rohan, Paolo Toniolo, Yu Shunzhang

Research output: Contribution to journalReview articlepeer-review

686 Scopus citations


We conducted a combined analysis of the original data to evaluate the consistency of 12 case-control studies of diet and breast cancer. Our analysis shows a consistent, statistically significant, positive association between breast cancer risk and saturated fat intake in postmenopausal women (relative risk for highest vs. lowest quintile, 1.46; P <.0001). A consistent protective effect for a number of markers of fruit and vegetable intake was demonstrated; vitamin C intake had the most consistent and statistically significant inverse association with breast cancer risk (relative risk for highest vs. lowest quintile, 0.69; P <.0001). If these dietary associations represent causality, the attributable risk (i.e., the percentage of breast cancers that might be prevented by dietary modification) in the North American population is estimated to be 24% for postmenopausal women and 16% for premeno-pausal women. [J Natl Cancer Inst 82: 561-569, 1990]

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalJournal of the National Cancer Institute
Issue number7
StatePublished - Apr 4 1990
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Dietary factors and risk of breast cancer: Combined analysis of 12 case - control studies'. Together they form a unique fingerprint.

Cite this