TY - JOUR
T1 - Diazepam in the management of heroin withdrawal in adolescents
T2 - Preliminary report
AU - Litt, Iris F.
AU - Colli, Anita S.
AU - Cohen, Michael I.
PY - 1971/4
Y1 - 1971/4
N2 - In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.
AB - In a group of mice experimentally addicted to morphine, diazepam eliminated the major manifestation of withdrawal. Diazepam was similarly effective in reducing the duration and severity of withdrawal symptoms in a large group of adolescent heroin addicts. The ideal agent for opiate detoxification is one which is nontoxic, nonaddictive, inexpensive, easily administered, and above all, effective in eliminating the potentially life-threatening consequences of withdrawal. On the basis of the animal experiment and clinical trial in adolescent heroin addicts reported herein, diazepam appears to fulfill these criteria.
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U2 - 10.1016/S0022-3476(71)80479-1
DO - 10.1016/S0022-3476(71)80479-1
M3 - Article
C2 - 4926621
AN - SCOPUS:0015043023
SN - 0022-3476
VL - 78
SP - 692
EP - 696
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 4
ER -