Developmental aspects of the upper airway: Report from an NHLBI Workshop, March 5-6, 2009

Carole L. Marcus, Richard J.H. Smith, Leila A. Mankarious, Raanan Arens, Gordon S. Mitchell, Ravindhra G. Elluru, Vito Forte, Steven Goudy, Ethylin W. Jabs, Alex A. Kane, Eliot Katz, David Paydarfar, Kevin Pereira, Roger H. Reeves, Joan T. Richtsmeier, Ramon L. Ruiz, Bradley T. Thach, David E. Tunkel, Jeffrey A. Whitsett, David WoottonCarol J. Blaisdell

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The upper airway serves three important functions: respiration, swallowing, andspeech.Duringdevelopment itundergoes significant structural and functional changes that affect its size, shape, and mechanical properties. Abnormalities of the upper airway require prompt attention, because these often alter ventilatory patterns and gas exchange, particularly during sleep when upper airway motor tone and ventilatory drive are diminished. Recognizing the relationship of early life events to lung health and disease, theNationalHeart, Lung, and Blood Institute (NHLBI), with cofunding fromthe Office of Rare Diseases (ORD), convened a workshop of extramural experts, from many disciplines. The objective of the workshop was: (1) to review the state of science in pediatric upper airway disorders; (2) to make recommendations to the Institute to fill knowledge gaps; (3) to prioritize new research directions; and (4) to capitalize on scientific opportunities. This report provides recommendations that could facilitate translation of basic research findings into practice to better diagnose, treat, and prevent airway compromise in children.

Original languageEnglish (US)
Pages (from-to)513-520
Number of pages8
JournalProceedings of the American Thoracic Society
Issue number6
StatePublished - Sep 15 2009

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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