Developing a time-resolved flow cytometer for fluorescence lifetime measurements of near-infrared fluorescent proteins

Zhihua Yang, Daria M. Shcherbakova, Vladislav V. Verkhusha, Jessica P. Houston

Research output: Contribution to journalConference articlepeer-review

Abstract

Excited state fluorescence lifetimes of near-infrared fluorescent proteins iRFP682 and iRFP713 engineered from bacterial phytochromes were measured with a time-resolved flow cytometer. Average lifetimes ranged between 0.5 and 1.0 ns for n=5000 bacterial cells. We anticipate cell sorting for screening cells expressing mutated iRFP variants of high quantum yield.

Original languageEnglish (US)
Article numberSW4G.1
JournalOptics InfoBase Conference Papers
StatePublished - 2016
EventCLEO: Science and Innovations, SI 2016 - San Jose, United States
Duration: Jun 5 2016Jun 10 2016

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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