Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

Seung Yub Lee; Fubo Liang; Xiao Ling Guo; Laiping Xie; Sean M. Cahill; Michael Blumenstein; Heyi Yang; David S. Lawrence; Zhong Yin Zhang

doi:10.1002/anie.200462004

Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

Seung Yub Lee, Fubo Liang, Xiao Ling Guo, Laiping Xie, Sean M. Cahill, Michael Blumenstein, Heyi Yang, David S. Lawrence, Zhong Yin Zhang

Biochemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

(Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended "warhead" protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.

Original language	English (US)
Pages (from-to)	4242-4244
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	27
DOIs	https://doi.org/10.1002/anie.200462004
State	Published - Jul 4 2005

Keywords

Drug delivery
Inhibitors
Peptides
Prodrugs
Signal transduction

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200462004

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title = "Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor",

abstract = "(Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended {"}warhead{"} protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.",

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T1 - Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

AU - Lee, Seung Yub

AU - Liang, Fubo

AU - Guo, Xiao Ling

AU - Xie, Laiping

AU - Cahill, Sean M.

AU - Blumenstein, Michael

AU - Yang, Heyi

AU - Lawrence, David S.

AU - Zhang, Zhong Yin

PY - 2005/7/4

Y1 - 2005/7/4

N2 - (Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended "warhead" protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.

AB - (Figure Presented) Ricin, diphtheria toxin, and other cytotoxic proteins are two-component systems which contain a carrier protein that biochemically silences the activity of the appended "warhead" protein until it is delivered into the cell. A cell-penetrating peptide (CPP) has been used in an analogous fashion (see picture) to suppress the activity of a PTP1B inhibitor that becomes activated by cleavage of the disulfide bridge upon cellular entry.

KW - Drug delivery

KW - Inhibitors

KW - Peptides

KW - Prodrugs

KW - Signal transduction

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JF - Angewandte Chemie - International Edition

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Design, construction, and intracellular activation of an intramolecularly self-silenced signal transduction inhibitor

Abstract

Keywords

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