TY - JOUR
T1 - Desferrioxamine Suppresses Plasmodium falciparum in Aotus Monkeys
AU - Pollack, Simeon
AU - Rossan, Richard N.
AU - Davidson, David E.
AU - Escajadillo, Alfonso
N1 - Funding Information:
This research was supported in part by U.S. Army Medical Research and Development Command contracts DAMD 17-83-C-3232 and DAMD 17-83-C-4215, and by grants HL 21560 and AI 20057 from the National Institutes of Health. This paper is contribution No. 1803 to the Army Research Program on Antiparasitic Drugs. The views of the author do not purport to reflect the positions of the U.S. Army or the U.S. Department of Defense. In conducting the research described in this report, the investigators adhered to the Guide for the Care and Use of Laboratory Animals, as promulgated by the National Research Council.
PY - 1987/2
Y1 - 1987/2
N2 - Clinical observation has suggested that iron deficiency may be protective in malaria, and we have found that desferrioxamine (DF), an iron-specific chelating agent, inhibited Plasmodium falciparum growth in vitro. It was difficult to be confident that DF would be effective in an intact animal, however, because continuous exposure to DF was required in vitro and, in vivo, DF is rapidly excreted. Also, the in vitro effect of DF was overcome by addition of iron to the culture and in vivo there are potentially high local iron concentrations when iron is absorbed from the diet or released from reticuloendothelial cells. We now show that DF given by constant subcutaneous infusion does suppress parasitemia in P. falciparum-infected Aotus monkeys.
AB - Clinical observation has suggested that iron deficiency may be protective in malaria, and we have found that desferrioxamine (DF), an iron-specific chelating agent, inhibited Plasmodium falciparum growth in vitro. It was difficult to be confident that DF would be effective in an intact animal, however, because continuous exposure to DF was required in vitro and, in vivo, DF is rapidly excreted. Also, the in vitro effect of DF was overcome by addition of iron to the culture and in vivo there are potentially high local iron concentrations when iron is absorbed from the diet or released from reticuloendothelial cells. We now show that DF given by constant subcutaneous infusion does suppress parasitemia in P. falciparum-infected Aotus monkeys.
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U2 - 10.3181/00379727-184-42461
DO - 10.3181/00379727-184-42461
M3 - Article
C2 - 3543939
AN - SCOPUS:0023123564
SN - 0037-9727
VL - 184
SP - 162
EP - 164
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -
