Dermatitis and alopecia

Yevgeniy Balagula, Mario E. Lacouture

Research output: Chapter in Book/Report/Conference proceedingChapter


A fundamental shift in chemotherapeutic approach has occurred over the last several decades. A new class of so-called targeted agents, designed to target aberrant molecular pathways responsible for promoting carcinogenesis, was added to the arsenal of cytotoxic drugs that target rapidly proliferating tumor cells. These advances improved patient care and decreased morbidity and mortality. While systemic adverse events such as bone marrow suppression and gastrointestinal toxicities have diminished with the use of targeted agents, the spectrum of dermatologic toxicities have expanded. Mechanisms underlying the development of such a variety of cutaneous adverse events remain to be elucidated, but a significant amount of data shedding light on potential pathophysiology has accumulated. This chapter will review these data.

Original languageEnglish (US)
Title of host publicationPathobiology of Cancer Regimen-Related Toxicities
PublisherSpringer New York
Number of pages20
ISBN (Print)9781461454380, 9781461454373
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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