TY - JOUR
T1 - Depressive symptoms and gait dysfunction in the elderly
AU - Brandler, Tamar C.
AU - Wang, Cuiling
AU - Oh-Park, Mooyeon
AU - Holtzer, Roee
AU - Verghese, Joe
N1 - Funding Information:
The Einstein Aging Study is funded by the National Institute on Aging (AG03949, PI: R.B. Lipton, M.D.) .
Funding Information:
Dr Verghese is funded by the National Institute on Aging (RO1 AG025119) . Ms Tamar Brandler is supported by the CTSA Grant UL1 RR025750 and TL1 RR025748 from the National Center for Research Resources.
PY - 2012/5
Y1 - 2012/5
N2 - Objective: Assess the association between depressive symptoms (not meeting the criteria for major depression) and gait dysfunction in older adults. Design: Cross-sectional study. Setting: Einstein Aging Study, a community-based longitudinal aging study. Participants: Six hundred ten nondemented and nondepressed community-residing adults age 70 and older. Measurements: Depressive symptoms measured using the 15-item Geriatric Depression Scale. To obtain a comprehensive assessment of gait, eight individual quantitative gait parameters were assessed: velocity (cm/s), stride length (cm), cadence (steps/min), swing phase (seconds), stance phase (seconds), double support phase (seconds), stride length variability (SD of stride length), and swing time variability (SD of swing time). Multiple linear regression analysis was applied to study the association of depressive symptoms with gait, adjusting for potential confounders including demographic variables, medical illnesses, and clinical gait abnormalities. Results: Increased level of depressive symptoms was associated with worse velocity, stride, and swing time variability. The relationship of the remaining five gait variables with depressive symptoms was not significant in the fully adjusted models. Conclusions: Higher levels of depressive symptoms are associated with worse performance in specific quantitative gait variables in community-residing older adults.
AB - Objective: Assess the association between depressive symptoms (not meeting the criteria for major depression) and gait dysfunction in older adults. Design: Cross-sectional study. Setting: Einstein Aging Study, a community-based longitudinal aging study. Participants: Six hundred ten nondemented and nondepressed community-residing adults age 70 and older. Measurements: Depressive symptoms measured using the 15-item Geriatric Depression Scale. To obtain a comprehensive assessment of gait, eight individual quantitative gait parameters were assessed: velocity (cm/s), stride length (cm), cadence (steps/min), swing phase (seconds), stance phase (seconds), double support phase (seconds), stride length variability (SD of stride length), and swing time variability (SD of swing time). Multiple linear regression analysis was applied to study the association of depressive symptoms with gait, adjusting for potential confounders including demographic variables, medical illnesses, and clinical gait abnormalities. Results: Increased level of depressive symptoms was associated with worse velocity, stride, and swing time variability. The relationship of the remaining five gait variables with depressive symptoms was not significant in the fully adjusted models. Conclusions: Higher levels of depressive symptoms are associated with worse performance in specific quantitative gait variables in community-residing older adults.
KW - Depressive symptoms
KW - Elderly
KW - Epidemiology
KW - Gait
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U2 - 10.1097/JGP.0b013e31821181c6
DO - 10.1097/JGP.0b013e31821181c6
M3 - Article
C2 - 21422907
AN - SCOPUS:84860225658
SN - 1064-7481
VL - 20
SP - 425
EP - 432
JO - American Journal of Geriatric Psychiatry
JF - American Journal of Geriatric Psychiatry
IS - 5
ER -