Definition of a small core transcriptional circuit regulated by AML1-ETO

Kristy R. Stengel; Jacob D. Ellis; Clare L. Spielman; Monica L. Bomber; Scott W. Hiebert

doi:10.1016/j.molcel.2020.12.005

Definition of a small core transcriptional circuit regulated by AML1-ETO

Kristy R. Stengel, Jacob D. Ellis, Clare L. Spielman, Monica L. Bomber, Scott W. Hiebert

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Stengel et al. combine PROTAC-mediated degradation of the oncogenic transcription factor AML1-ETO with nascent transcript analysis to identify direct gene targets. AML1-ETO-mediated repression of this small gene network impairs myeloid differentiation. This provides a model for the identification of transcriptional circuits directly controlled by transcription factors.

Original language	English (US)
Pages (from-to)	530-545.e5
Journal	Molecular Cell
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2020.12.005
State	Published - Feb 4 2021
Externally published	Yes

Keywords

AML1-ETO
PRO-seq
PROTAC
RUNX1
RUNX1T1
degron tag
myeloid leukemia
nascent transcription

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.12.005

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title = "Definition of a small core transcriptional circuit regulated by AML1-ETO",

abstract = "Stengel et al. combine PROTAC-mediated degradation of the oncogenic transcription factor AML1-ETO with nascent transcript analysis to identify direct gene targets. AML1-ETO-mediated repression of this small gene network impairs myeloid differentiation. This provides a model for the identification of transcriptional circuits directly controlled by transcription factors.",

keywords = "AML1-ETO, PRO-seq, PROTAC, RUNX1, RUNX1T1, degron tag, myeloid leukemia, nascent transcription",

author = "Stengel, {Kristy R.} and Ellis, {Jacob D.} and Spielman, {Clare L.} and Bomber, {Monica L.} and Hiebert, {Scott W.}",

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AU - Ellis, Jacob D.

AU - Spielman, Clare L.

AU - Bomber, Monica L.

AU - Hiebert, Scott W.

PY - 2021/2/4

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AB - Stengel et al. combine PROTAC-mediated degradation of the oncogenic transcription factor AML1-ETO with nascent transcript analysis to identify direct gene targets. AML1-ETO-mediated repression of this small gene network impairs myeloid differentiation. This provides a model for the identification of transcriptional circuits directly controlled by transcription factors.

KW - AML1-ETO

KW - PRO-seq

KW - PROTAC

KW - RUNX1

KW - RUNX1T1

KW - degron tag

KW - myeloid leukemia

KW - nascent transcription

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Definition of a small core transcriptional circuit regulated by AML1-ETO

Abstract

Keywords

ASJC Scopus subject areas

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