Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Grigory S. Filonov; Arie Krumholz; Jun Xia; Junjie Yao; Lihong V. Wang; Vladislav V. Verkhusha

doi:10.1002/anie.201107026

Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Grigory S. Filonov, Arie Krumholz, Jun Xia, Junjie Yao, Lihong V. Wang, Vladislav V. Verkhusha

Genetics

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.

Original language	English (US)
Pages (from-to)	1448-1451
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	6
DOIs	https://doi.org/10.1002/anie.201107026
State	Published - Feb 6 2012

Keywords

absorption
cancer
fluorescent proteins
imaging agents
photoacoustic imaging

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201107026

Cite this

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abstract = "Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.",

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AU - Xia, Jun

AU - Yao, Junjie

AU - Wang, Lihong V.

AU - Verkhusha, Vladislav V.

PY - 2012/2/6

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AB - Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.

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KW - fluorescent proteins

KW - imaging agents

KW - photoacoustic imaging

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Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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