Deep Cerebellar Nuclei Rebound Firing In Vivo: Much Ado About Almost Nothing?

Davide Reato, Esra Tara, Kamran Khodakhah

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


How the output neurons of the cerebellum, the neurons of the deep cerebellar nuclei (DCN), encode information remains a matter of much debate. DCN neurons have the requisite biophysical characteristics to exhibit rebound firing and fire a brief but high-frequency burst of action potentials after pauses brought about by strong hyperpolarizations. Rebound firing is an attractive coding mechanism as it can provide a timed signal with a high signal-to-noise ratio to downstream motor areas. However, whether DCN rebound firing is a common signaling mechanism under physiological conditions remains to be demonstrated. We analyzed postpause firing rates of DCN neurons in awake animals in vivo under a number of behavioral conditions, including cerebellar-intensive behaviors such as balancing on a beam and walking on a treadmill. We did not find any evidence in support of a role for rebound firing in encoding information under any of these behavioral conditions.

Original languageEnglish (US)
Title of host publicationThe Neuronal Codes of the Cerebellum
PublisherElsevier Inc.
Number of pages25
ISBN (Print)9780128013861
StatePublished - 2016


  • Cerebellum
  • Deep cerebellar nuclei
  • Purkinje cells
  • Rate code
  • Rebound firing
  • Timing code

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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