Decreased DNA repair capacity in familial, but not in sporadic Alzheimer's disease

Michael E.T.I. Boerrigter, Cornelia M. Van Duijn, Erik Mullaart, Piet Eikelenboom, Cees M.A. Van Der Togt, Dick L. Knook, Albert Hofman, Jan Vijg

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Using the alkaline filter elution technique we determined the induction and disappearance of DNA single-strand breaks (SSB) in freshly isolated peripheral blood lymphocytes (PBL) from 43 Alzheimer's disease (AD) patients and 48 normal, healthy age- and sex-matched control subjects following in vitro exposure to N-ethyl-N-nitrosourea (ENU). The mean percentage SSB disappearance in PBL from control subjects at 1 h after ENU treatment was 41.4 ± 2.9%; this was not significantly different from that found in samples from AD patients which had no (n = 16) or one (n = 12) first-degree relative with dementia (42.5 ± 8.2% and 43.0 ± 4.4%, respectively; p>0.75). However, in PBL of 15 AD patients with at least two first-degree relatives with dementia the mean percentage SSB disappearance was 23.6 ± 5.8%, which was significantly lower than that found in controls (p<0.01) or in the other AD patients (p<0.02).

Original languageEnglish (US)
Pages (from-to)367-370
Number of pages4
JournalNeurobiology of Aging
Issue number4
StatePublished - 1991
Externally publishedYes


  • Alkaline elution
  • Alzheimer
  • DNA repair
  • Ethylnitrosourea
  • Lymphocytes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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