Deconstructing craving: Dissociable cortical control of Cue reactivity in nicotine addiction

Daniel Scott, Noboru Hiroi

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Background: Cue reactivity, the ability of cues associated with addictive substances to induce seeking and withdrawal, is a major contributor to addiction. Although human imaging studies show that cigarette-associated cues simultaneously activate the insula and the orbitofrontal cortex and evoke craving, how these activities functionally contribute to distinct elements of cue reactivity remains unclear. Moreover, it remains unclear whether the simultaneous activation of these cortical regions reflects coordinated functional connectivity or parallel processing. Methods: We selectively lesioned the insula or orbitofrontal cortex with the excitotoxin ibotenic acid in mice, and their approach to nicotine-associated cues (n = 613/group) and avoidance of withdrawal-associated cues (n = 512/group) were separately examined in place conditioning paradigms. We additionally tested the role of these two cortical structures in approach to food-associated cues (n = 67/group) and avoidance of lithium chloride-associated cues (n = 67/group). Results: Our data show a double dissociation in which excitotoxic lesions of the insula and orbitofrontal cortex selectively disrupted nicotine-induced cue approach and withdrawal-induced cue avoidance, respectively. These effects were not entirely generalized to approach to food-associated cues or avoidance of lithium chloride-associated cues. Conclusions: Our data provide functional evidence that cue reactivity seen in addiction includes unique neuroanatomically dissociable elements and suggest that the simultaneous activation of these two cortical regions in response to smoking-related cues does not necessarily indicate functional connectivity.

Original languageEnglish (US)
Pages (from-to)1052-1059
Number of pages8
JournalBiological Psychiatry
Issue number11
StatePublished - Jun 1 2011


  • Cue reactivity
  • incentive
  • insula
  • nicotine
  • orbitofrontal cortex
  • withdrawal

ASJC Scopus subject areas

  • Biological Psychiatry


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