Decision Analysis in Formulary Decision Making

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11 Scopus citations


Although decision making about what drugs to include in an institutional formulary appears to lend itself readily to quantitative techniques such as decision analysis and cost-benefit analysis, a review of the literature reveals that very little has been published in this area. Several of the published decision analyses use non-standard techniques that are, at best, of unproved validity, and may seriously distort the underlying issues through covert under-counting or double-counting of various drug attributes. Well executed decision analyses have contributed to establishing that drug acquisition costs are not an adequate measure of the total economic impact of formulary decisions and that costs of labour and materials associated with drug administration must be calculated on an institution-specific basis to reflect unique staffing patterns, bulk purchasing practices, and the availability of surplus capacity within the institution which might be mobilised at little marginal cost. Clinical studies of newly introduced drugs frequently fail to answer the questions that weigh most heavily on the structuring of a formal assessment of a proposed formulary acquisition. Studies comparing a full spectrum of therapeutically equivalent drugs are rarely done, and individual studies of particular pairs of drugs can rarely be used together because of differences in methodology or patient populations studied. Gathering of institution-specific economic and clinical data is a daunting, labour-intensive task. In many institutions, incentive and reward structures discourage behaviour that takes the broad institutional perspective that is intrinsic to a good decision analysis. Many institutions have neither the structure nor the culture to support the broad interdisciplinary cooperation required both to carry our decision analyses and to implement the decisions based on them. Recommendations to broaden the application of decision analysis to formulary decision making include: (1) development and marketing of updated, inexpensive software which exploits the advantages of currently available desktop computers and user interfaces; (2) research to develop and validate measures based on easily obtained information which can replace the relatively inaccessible data required for direct application of decision analysis to formulary decisions; (3) institutional development of standing multidisciplinary committees on quantitative decision-making methods; (4) further research in decision analytic technique to simplify the problem posed by the large number of combinations of drugs that may be chosen for a formulary.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
Issue number6
StatePublished - Jun 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy
  • Public Health, Environmental and Occupational Health


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