TY - JOUR
T1 - Daily luteal serum and urinary hormone profiles in the menopause transition
T2 - Study of Women's Health Across the Nation
AU - Santoro, Nanette
AU - El Khoudary, Samar R.
AU - Nasr, Alexis
AU - Gold, Ellen B.
AU - Greendale, Gail
AU - Mcconnell, Dan
AU - Neal-Perry, Genevieve
AU - Pavlovic, Jelena
AU - Derby, Carol
AU - Crawford, Sybil
N1 - Funding Information:
Funding/support: The Study of Women’s Health Across the Nation (SWAN) has grant support from the National Institutes of Health (NIH), DHHS, through the National Institute on Aging (NIA), the National Institute of Nursing Research (NINR), and the NIH Office of Research on Women’s Health (ORWH) (Grants U01NR004061; U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495). The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the NIA, NINR, ORWH, or the NIH. This publication was supported in part by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1 RR024131.
Publisher Copyright:
© 2020 by The North American Menopause Society.
PY - 2020
Y1 - 2020
N2 - Objective:To further characterize the endocrinology of the menopause transition, we sought to determine: whether relationships between urine and serum hormones are maintained as women enter their sixth decade; whether a single luteal phase serum progesterone (P) is reflective of integrated-luteal urinary pregnanediol glucuronide (uPdg); and whether serum P, like luteal uPdg, declines as women approach their final menses (FMP).Methods:The Study of Women's Health Across the Nation (SWAN) Daily Hormone Study's (DHS) is a community-based observational study. A subset of participants underwent a timed, luteal blood draw planned for cycle days 16 to 24 during the same month of DHS collection. Serum-luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol and P, and urine LH, FSH, estrone conjugates (E1c), and daily and integrated luteal uPdg were measured in 268 samples from 170 women. Serum/urine hormone associations were determined using Pearson's correlation and linear regression, adjusted for concurrent age, body mass index, smoking status, and race/ethnicity.Results:Pearson's r ranged from 0.573 (for LH) to 0.843 (for FSH) for serum/urine correlations. Integrated luteal uPdg weakly correlated with serum P (Pearson's r=0.26, P=0.004) and explained 7% of the variability in serum P in adjusted linear regression (total R2 0.09, P=0.002). Serum P demonstrated a marginally significant decline with approaching FMP in adjusted analysis (P=0.04).Conclusions:Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion.
AB - Objective:To further characterize the endocrinology of the menopause transition, we sought to determine: whether relationships between urine and serum hormones are maintained as women enter their sixth decade; whether a single luteal phase serum progesterone (P) is reflective of integrated-luteal urinary pregnanediol glucuronide (uPdg); and whether serum P, like luteal uPdg, declines as women approach their final menses (FMP).Methods:The Study of Women's Health Across the Nation (SWAN) Daily Hormone Study's (DHS) is a community-based observational study. A subset of participants underwent a timed, luteal blood draw planned for cycle days 16 to 24 during the same month of DHS collection. Serum-luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol and P, and urine LH, FSH, estrone conjugates (E1c), and daily and integrated luteal uPdg were measured in 268 samples from 170 women. Serum/urine hormone associations were determined using Pearson's correlation and linear regression, adjusted for concurrent age, body mass index, smoking status, and race/ethnicity.Results:Pearson's r ranged from 0.573 (for LH) to 0.843 (for FSH) for serum/urine correlations. Integrated luteal uPdg weakly correlated with serum P (Pearson's r=0.26, P=0.004) and explained 7% of the variability in serum P in adjusted linear regression (total R2 0.09, P=0.002). Serum P demonstrated a marginally significant decline with approaching FMP in adjusted analysis (P=0.04).Conclusions:Urine and serum hormones maintain a close relationship in women into their sixth decade of life. Serum luteal P was weakly reflective of luteal Pdg excretion.
KW - Estradiol
KW - FSH
KW - LH
KW - Menstrual cycle
KW - Progesterone
KW - Reproductive aging
UR - http://www.scopus.com/inward/record.url?scp=85078692191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078692191&partnerID=8YFLogxK
U2 - 10.1097/GME.0000000000001453
DO - 10.1097/GME.0000000000001453
M3 - Article
C2 - 31794501
AN - SCOPUS:85078692191
SN - 1072-3714
VL - 27
SP - 127
EP - 133
JO - Menopause
JF - Menopause
IS - 2
ER -