Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats

Nandor Ludvig; Solomon L. Moshé

doi:10.1016/0006-8993(87)91545-9

Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats

Nandor Ludvig, Solomon L. Moshé

Neurology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Microinjection of 10 μg of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.

Original language	English (US)
Pages (from-to)	193-196
Number of pages	4
Journal	Brain research
Volume	437
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)91545-9
State	Published - Dec 22 1987

Keywords

Audiogenic seizure
Conculsion
Cyclic AMP
Ingerior colliculus
Rat

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)91545-9

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abstract = "Microinjection of 10 μg of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.",

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AU - Moshé, Solomon L.

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Y1 - 1987/12/22

N2 - Microinjection of 10 μg of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.

AB - Microinjection of 10 μg of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior colliculus or in the substantia nigra-region did not induce any such effects. These data suggest that there may be a close relationship between audiogenic seizures and cyclic AMP metabolism of the inferior colliculus.

KW - Audiogenic seizure

KW - Conculsion

KW - Cyclic AMP

KW - Ingerior colliculus

KW - Rat

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Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats

Abstract

Keywords

ASJC Scopus subject areas

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