Cutaneous, purpuric painful nodules upon addition of ibrutinib to RCVP therapy in a CLL patient: A distinctive reaction pattern reflecting iatrogenic Th2 to Th1 milieu reversal

Joseph Justin Mulvey; Gerard J. Nuovo; Cynthia M. Magro

doi:10.1097/DAD.0000000000000441

Cutaneous, purpuric painful nodules upon addition of ibrutinib to RCVP therapy in a CLL patient: A distinctive reaction pattern reflecting iatrogenic Th2 to Th1 milieu reversal

Joseph Justin Mulvey, Gerard J. Nuovo, Cynthia M. Magro

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

A 70-year-old white man with stage C chronic lymphocytic leukemia who was being successfully treated with ibrutinib and rituximab developed bilateral, purpuric, painful cutaneous nodules. Biopsies of these nodules did not reveal the usual Th2 milieu of chronic lymphocytic leukemia but instead exhibited a Th1-rich lymphocytic infiltrate with resultant neutrophil and granulomatous inflammation. The eruption resolved with drug cessation emphasizing the potential importance of this drug in treating conditions associated with Th2 dysregulation.

Original language	English (US)
Pages (from-to)	492-498
Number of pages	7
Journal	American Journal of Dermatopathology
Volume	38
Issue number	7
DOIs	https://doi.org/10.1097/DAD.0000000000000441
State	Published - Jul 1 2016
Externally published	Yes

Keywords

Cutaneous nodules
Ibrutinib
Ibrutinib side-effect
Purpuric nodules
Th1
Th2

ASJC Scopus subject areas

Pathology and Forensic Medicine
Dermatology

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10.1097/DAD.0000000000000441

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Cutaneous, purpuric painful nodules upon addition of ibrutinib to RCVP therapy in a CLL patient: A distinctive reaction pattern reflecting iatrogenic Th2 to Th1 milieu reversal. / Mulvey, Joseph Justin; Nuovo, Gerard J.; Magro, Cynthia M.
In: American Journal of Dermatopathology, Vol. 38, No. 7, 01.07.2016, p. 492-498.

Research output: Contribution to journal › Article › peer-review

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abstract = "A 70-year-old white man with stage C chronic lymphocytic leukemia who was being successfully treated with ibrutinib and rituximab developed bilateral, purpuric, painful cutaneous nodules. Biopsies of these nodules did not reveal the usual Th2 milieu of chronic lymphocytic leukemia but instead exhibited a Th1-rich lymphocytic infiltrate with resultant neutrophil and granulomatous inflammation. The eruption resolved with drug cessation emphasizing the potential importance of this drug in treating conditions associated with Th2 dysregulation.",

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Cutaneous, purpuric painful nodules upon addition of ibrutinib to RCVP therapy in a CLL patient: A distinctive reaction pattern reflecting iatrogenic Th2 to Th1 milieu reversal

Abstract

Keywords

ASJC Scopus subject areas

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