TY - JOUR
T1 - Current Understanding of Moyamoya Disease (MMD) and Associated Neuropsychiatric Outcomes
AU - Antonov, Alexei
AU - Terraciano, Anthony
AU - Essibayi, Muhammed Amir
AU - Altschul, David J.
AU - Javed, Kainaat
N1 - Publisher Copyright:
© 2023 Antonov et al.
PY - 2023
Y1 - 2023
N2 - Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing and occlusion of the intracranial internal carotid arteries, leading to the formation of abnormal collateral vessels. MMD primarily affects the cerebrovascular system, and evidence suggests it is associated with various neuropsychiatric outcomes. This manuscript aims to provide an overview of the current understanding of MMD, including its epidemiology, pathophysiology, clinical manifestations, and diagnosis. Furthermore, it explores the emerging research on the neuropsychiatric sequelae of MMD, such as cognitive impairment, psychiatric disorders, and quality of life. The manuscript concludes with the challenges in managing MMD-related neuropsychiatric outcomes and potential avenues for future research.
AB - Moyamoya disease (MMD) is a rare cerebrovascular disorder characterized by the progressive narrowing and occlusion of the intracranial internal carotid arteries, leading to the formation of abnormal collateral vessels. MMD primarily affects the cerebrovascular system, and evidence suggests it is associated with various neuropsychiatric outcomes. This manuscript aims to provide an overview of the current understanding of MMD, including its epidemiology, pathophysiology, clinical manifestations, and diagnosis. Furthermore, it explores the emerging research on the neuropsychiatric sequelae of MMD, such as cognitive impairment, psychiatric disorders, and quality of life. The manuscript concludes with the challenges in managing MMD-related neuropsychiatric outcomes and potential avenues for future research.
KW - cerebrovascular disorder
KW - cognitive impairment
KW - moyamoya disease
KW - neuropsychiatric outcomes
KW - psychiatric disorders
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U2 - 10.2147/NDT.S402375
DO - 10.2147/NDT.S402375
M3 - Review article
AN - SCOPUS:85178903595
SN - 1176-6328
VL - 19
SP - 2673
EP - 2680
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
ER -