Current treatment practice and outcomes. Report of the hyponatremia registry

Arthur Greenberg, Joseph G. Verbalis, Alpesh N. Amin, Volker R. Burst, Joseph A. Chiodo, Jun R. Chiong, Joseph F. Dasta, Keith E. Friend, Paul J. Hauptman, Alessandro Peri, Samuel H. Sigal

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


Current management practices for hyponatremia (HN) are incompletely understood. The HN Registry has recorded diagnostic measures, utilization, efficacy, and outcomes of therapy for eu- or hypervolemic HN. To better understand current practices, we analyzed data from 3087 adjudicated adult patients in the registry with serum sodium concentration of 130 mEq/l or less from 225 sites in the United States and European Union. Common initial monotherapy treatments were fluid restriction (35%), administration of isotonic (15%) or hypertonic saline (2%), and tolvaptan (5%); 17% received no active agent. Median (interquartile range) mEq/l serum sodium increases during the first day were as follows: no treatment, 1.0 (0.0-4.0); fluid restriction, 2.0 (0.0-4.0); isotonic saline, 3.0 (0.0-5.0); hypertonic saline, 5.0 (1.0-9.0); and tolvaptan, 4.0 (2.0-9.0). Adjusting for initial serum sodium concentration with logistic regression, the relative likelihoods for correction by 5 mEq/l or more (referent, fluid restriction) were 1.60 for hypertonic saline and 2.55 for tolvaptan. At discharge, serum sodium concentration was under 135 mEq/l in 78% of patients and 130 mEq/l or less in 49%. Overly rapid correction occurred in 7.9%. Thus, initial HN treatment often uses maneuvers of limited efficacy. Despite an association with poor outcomes and availability of effective therapy, most patients with HN are discharged from hospital still hyponatremic. Studies to assess short- and long-term benefits of correction of HN with effective therapies are needed.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalKidney international
Issue number1
StatePublished - Jul 2 2015
Externally publishedYes


  • Acid-base and electrolytes
  • Geriatric nephrology
  • Vasopressin
  • Water and volume homeostasis

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Current treatment practice and outcomes. Report of the hyponatremia registry'. Together they form a unique fingerprint.

Cite this