Current practice and evolving concepts in septic shock resuscitation

Jan Bakker, Eduardo Kattan, Djillali Annane, Ricardo Castro, Maurizio Cecconi, Daniel De Backer, Arnaldo Dubin, Laura Evans, Michelle Ng Gong, Olfa Hamzaoui, Can Ince, Bruno Levy, Xavier Monnet, Gustavo A.Ospina Tascón, Marlies Ostermann, Michael R. Pinsky, James A. Russell, Bernd Saugel, Thomas W.L. Scheeren, Jean Louis TeboulAntoine Vieillard Baron, Jean Louis Vincent, Fernando G. Zampieri, Glenn Hernandez

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations


Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. Even though large randomized, controlled trials have addressed fundamental aspects of septic shock resuscitation, many questions still exist. In this review, we will describe the current standards of septic shock resuscitation, but the emphasis will be placed on evolving concepts in different domains such as clinical resuscitation targets, adequate use of fluids and vasoactive drugs, refractory shock, and the use of extracorporeal therapies. Multiple research opportunities remain open, and collaborative endeavors should be performed to fill in these gaps.

Original languageEnglish (US)
Pages (from-to)148-163
Number of pages16
JournalIntensive Care Medicine
Issue number2
StatePublished - Feb 2022


  • Fluid resuscitation
  • Fluids
  • Intensive care
  • Sepsis
  • Treatment
  • Vasoactive drugs

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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