Cryptococcus neoformans-Specific and Non-Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients with and Without Cryptococcosis

Hyunah Yoon; Antonio Nakouzi; Peter G. Pappas; Vagish S. Hemmige; Liise Anne Pirofski

doi:10.1093/ofid/ofac211

Cryptococcus neoformans-Specific and Non-Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients with and Without Cryptococcosis

Hyunah Yoon, Antonio Nakouzi, Peter G. Pappas, Vagish S. Hemmige, Liise Anne Pirofski

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.

Original language	English (US)
Article number	ofac211
Journal	Open Forum Infectious Diseases
Volume	9
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofac211
State	Published - Jul 1 2022

Keywords

IgM
cryptococcosis
glucuronoxylomannan
laminarin
transplant recipients

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofac211

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title = "Cryptococcus neoformans-Specific and Non-Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients with and Without Cryptococcosis",

abstract = "Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.",

keywords = "IgM, cryptococcosis, glucuronoxylomannan, laminarin, transplant recipients",

author = "Hyunah Yoon and Antonio Nakouzi and Pappas, {Peter G.} and Hemmige, {Vagish S.} and Pirofski, {Liise Anne}",

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doi = "10.1093/ofid/ofac211",

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T1 - Cryptococcus neoformans-Specific and Non-Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients with and Without Cryptococcosis

AU - Yoon, Hyunah

AU - Nakouzi, Antonio

AU - Pappas, Peter G.

AU - Hemmige, Vagish S.

AU - Pirofski, Liise Anne

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.

AB - Antibody immunity has not been studied in organ transplant recipients (OTRs) with cryptococcosis. We determined serum antibody levels in OTRs: 23 cryptococcosis cases and 21 controls. Glucuronoxylomannan immunoglobulin M (IgM) and laminarin IgM were lower in cases than controls, were inversely associated with cryptococcosis status, and may hold promise as markers of cryptococcosis.

KW - IgM

KW - cryptococcosis

KW - glucuronoxylomannan

KW - laminarin

KW - transplant recipients

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Cryptococcus neoformans-Specific and Non-Cryptococcus neoformans-Specific Antibody Profiles in Organ Transplant Recipients with and Without Cryptococcosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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