Cross-linking activities of galectins and other multivalent lectins

C. Fred Brewer

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The multivalent binding activities of lectins including certain galectins lead to the formation of type-1 and type-2 cross-linked complexes with multivalent carbohydrates and glycoconjugates. Type-1 complexes occur between divalent lectins and divalent carbohydrates or glycoconjugates which yield 1-dimensional cross-linked complexes. This type of complex has been observed between galectin-1 from bovine heart muscle and a bivalent N-linked biantennary complex glycopeptide (Bourne et al., 1994). Type-2 interactions occur between lectins and carbohydrates or glycoconjugates where one of the two molecules possesses a valency greater than two. In this case, 2- and 3-dimensional cross-linking occurs which may be homogeneous if crystal packing interactions are present. Evidence indicates that calf spleen galectin-1 undergo type-2 cross-linking interactions with ASF (Gupta and Brewer, 1994). The flexibility of certain galectins such as galectin-1 to form type-1 and type-2 cross-linked complexes with carbohydrates and glycoconjugates may relate to the biological activities of this animal lectin, and to the activities of other members of the galectin family.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalTrends in Glycoscience and Glycotechnology
Issue number45
StatePublished - 1997


  • Cross-linking
  • Lattices
  • Multivalency
  • Specificity

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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