Coordinated Regulation of Adipose Tissue Macrophages by Cellular and Nutritional Signals

Daniel Har, Michelle Carey, Meredith Hawkins

Research output: Contribution to journalArticlepeer-review


The current epidemic of obesity is fueling a global rise in non-communicable diseases, including type 2 diabetes mellitus, atherothrombotic disease, and cancer. Obesity is associated with systemic inflammation, with various fat-derived inflammatory factors being implicated in the pathophysiology of insulin resistance. The infiltration of various types of inflammatory cells into adipose tissue seems to be an important mechanism whereby nutrient excess contributes to systemic insulin resistance. In particular, adipose tissue macrophages are abundant in obese adipose tissue, and may be the source of the majority of fat-derived circulating inflammatory factors. This review examines recent studies exploring mechanisms whereby cellular and nutritional signals mediate macrophage recruitment to adipose tissue and their pro-inflammatory activation.

Original languageEnglish (US)
Pages (from-to)937-941
Number of pages5
JournalJournal of Investigative Medicine
Issue number6
StatePublished - 2013
Externally publishedYes


  • cytokines
  • free fatty acids
  • regulation of adipose tissue macrophages

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


Dive into the research topics of 'Coordinated Regulation of Adipose Tissue Macrophages by Cellular and Nutritional Signals'. Together they form a unique fingerprint.

Cite this