Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA

Ariana M. Stickel, Wassim Tarraf, Sayaka Kuwayama, Benson Wu, Erin E. Sundermann, Linda C. Gallo, Melissa Lamar, Martha Daviglus, Donglin Zeng, Bharat Thyagarajan, Carmen R. Isasi, Richard B. Lipton, Christina Cordero, Krista M. Perreira, Hector M. Gonzalez, Sarah J. Banks

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women. METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos-Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7-year change, and mild cognitive impairment [MCI] prevalence). RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence. DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.

Original languageEnglish (US)
Pages (from-to)1944-1957
Number of pages14
JournalAlzheimer's and Dementia
Issue number3
StatePublished - Mar 2024


  • Hispanics
  • Latinas
  • cognition
  • menopause
  • mild cognitive impairment
  • reproductive health
  • women

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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