Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA

Ariana M. Stickel; Wassim Tarraf; Sayaka Kuwayama; Benson Wu; Erin E. Sundermann; Linda C. Gallo; Melissa Lamar; Martha Daviglus; Donglin Zeng; Bharat Thyagarajan; Carmen R. Isasi; Richard B. Lipton; Christina Cordero; Krista M. Perreira; Hector M. Gonzalez; Sarah J. Banks

doi:10.1002/alz.13575

Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA

Ariana M. Stickel, Wassim Tarraf, Sayaka Kuwayama, Benson Wu, Erin E. Sundermann, Linda C. Gallo, Melissa Lamar, Martha Daviglus, Donglin Zeng, Bharat Thyagarajan, Carmen R. Isasi, Richard B. Lipton, Christina Cordero, Krista M. Perreira, Hector M. Gonzalez, Sarah J. Banks

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women. METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos-Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7-year change, and mild cognitive impairment [MCI] prevalence). RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence. DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.

Original language	English (US)
Pages (from-to)	1944-1957
Number of pages	14
Journal	Alzheimer's and Dementia
Volume	20
Issue number	3
DOIs	https://doi.org/10.1002/alz.13575
State	Published - Mar 2024

Keywords

Hispanics
Latinas
cognition
menopause
mild cognitive impairment
reproductive health
women

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/alz.13575

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Stickel, A. M., Tarraf, W., Kuwayama, S., Wu, B., Sundermann, E. E., Gallo, L. C., Lamar, M., Daviglus, M., Zeng, D., Thyagarajan, B., Isasi, C. R., Lipton, R. B., Cordero, C., Perreira, K. M., Gonzalez, H. M., & Banks, S. J. (2024). Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA. Alzheimer's and Dementia, 20(3), 1944-1957. https://doi.org/10.1002/alz.13575

Stickel, AM, Tarraf, W, Kuwayama, S, Wu, B, Sundermann, EE, Gallo, LC, Lamar, M, Daviglus, M, Zeng, D, Thyagarajan, B, Isasi, CR , Lipton, RB, Cordero, C, Perreira, KM, Gonzalez, HM & Banks, SJ 2024, 'Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA', Alzheimer's and Dementia, vol. 20, no. 3, pp. 1944-1957. https://doi.org/10.1002/alz.13575

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abstract = "INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women. METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos-Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7-year change, and mild cognitive impairment [MCI] prevalence). RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence. DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.",

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doi = "10.1002/alz.13575",

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AU - Stickel, Ariana M.

AU - Tarraf, Wassim

AU - Kuwayama, Sayaka

AU - Wu, Benson

AU - Sundermann, Erin E.

AU - Gallo, Linda C.

AU - Lamar, Melissa

AU - Daviglus, Martha

AU - Zeng, Donglin

AU - Thyagarajan, Bharat

AU - Isasi, Carmen R.

AU - Lipton, Richard B.

AU - Cordero, Christina

AU - Perreira, Krista M.

AU - Gonzalez, Hector M.

AU - Banks, Sarah J.

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N2 - INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women. METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos-Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7-year change, and mild cognitive impairment [MCI] prevalence). RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence. DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.

AB - INTRODUCTION: Reproductive health history may contribute to cognitive aging and risk for Alzheimer's disease, but this is understudied among Hispanic/Latina women. METHODS: Participants included 2126 Hispanic/Latina postmenopausal women (44 to 75 years) from the Study of Latinos-Investigation of Neurocognitive Aging. Survey linear regressions separately modeled the associations between reproductive health measures (age at menarche, history of oral contraceptive use, number of pregnancies, number of live births, age at menopause, female hormone use at Visit 1, and reproductive span) with cognitive outcomes at Visit 2 (performance, 7-year change, and mild cognitive impairment [MCI] prevalence). RESULTS: Younger age at menarche, oral contraceptive use, lower pregnancies, lower live births, and older age at menopause were associated with better cognitive performance. Older age at menarche was protective against cognitive change. Hormone use was linked to lower MCI prevalence. DISCUSSION: Several aspects of reproductive health appear to impact cognitive aging among Hispanic/Latina women.

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Connections between reproductive health and cognitive aging among women enrolled in the HCHS/SOL and SOL-INCA

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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