TY - JOUR
T1 - Concordance Between Self-Reported Medical Diagnosis of Mild Cognitive Impairment/Dementia and Neurocognitive Function Among Middle-Aged and Older Hispanic/Latino Adults
T2 - Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)
AU - Vásquez, Priscilla M.
AU - Tarraf, Wassim
AU - Li, Yuyi
AU - Jenkins, Derek
AU - Soria-Lopez, Jose A.
AU - Zlatar, Zvinka Z.
AU - Marquine, Maria J.
AU - Stickel, Ariana M.
AU - Estrella, Mayra L.
AU - Gallo, Linda C.
AU - Lipton, Richard B.
AU - Isasi, Carmen R.
AU - Cai, Jianwen
AU - Zeng, Donglin
AU - Daviglus, Martha L.
AU - Schneiderman, Neil
AU - González, Hector M.
N1 - Funding Information:
PMV is currently supported by National Institute on Minority Health and Health Disparities of the National Institutes of Health under award number S21 MD000103. PMV was supported by the National Institute on Aging of the National Institutes of Health under Award Number R56AG048642, the T32 Integrated Cardiovascular Disease Epidemiology Fellowship 5T32HL079891-13, and PMV, MM, ZZZ, and AMS were supported by the Alzheimer’s Disease Resource Center for advancing Minority Aging Research at the University of California San Diego under Award Number P30AG059299. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2022-IOS Press. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: Population-based studies typically rely on self-reported medical diagnosis (SRMD) of mild cognitive impairment (MCI)/dementia; however, links to objective neurocognitive function have not been established. Objective: Examine the association between SRMD of MCI/dementia and objective neurocognitive function among Hispanic/Latino adults. Methods: We conducted a case-control study using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) baseline data and its ancillary SOL-Investigation of Neurocognitive Aging (SOL-INCA) at visit 2. Hispanic/Latino adults aged 50 years and older (n = 593) were administered neurocognitive tests: the Six-Item Screener (SIS), Brief-Spanish English Verbal Learning Test (B-SVELT Sum), B-SVELT Recall, Word Fluency Test (WF), Digit Symbol Substitution Test (DSS), and Trail Making Test A and B. Individual and global neurocognitive function scores were used for analyses. Propensity matching techniques and survey generalized linear regression models were used to compare SRMD of MCI/dementia with demographic, psychological, and cardiovascular risk matched controls. Complex survey design methods were applied. Results: There were 121 cases of SRMD of MCI/dementia and 472 propensity matched controls. At baseline, compared to matched controls, cases showed no differences in neurocognitive function (p > 0.05). At SOL-INCA visit 2, cases had poorer scores in global neurocognitive function (p < 0.05), B-SEVLT Sum, B-SEVLT Recall, WF, DSS, and Trail A (p < 0.01). Conclusion: Observed differences in neurocognitive test scores between SRMD of MCI/dementia cases and matched controls were present at visit 2, but not at baseline in middle-aged and older Hispanic/Latino adults. These findings present initial evidence of the potential utility of SRMD of MCI/dementia in epidemiologic studies, where obtaining confirmation of diagnosis may not be feasible.
AB - Background: Population-based studies typically rely on self-reported medical diagnosis (SRMD) of mild cognitive impairment (MCI)/dementia; however, links to objective neurocognitive function have not been established. Objective: Examine the association between SRMD of MCI/dementia and objective neurocognitive function among Hispanic/Latino adults. Methods: We conducted a case-control study using the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) baseline data and its ancillary SOL-Investigation of Neurocognitive Aging (SOL-INCA) at visit 2. Hispanic/Latino adults aged 50 years and older (n = 593) were administered neurocognitive tests: the Six-Item Screener (SIS), Brief-Spanish English Verbal Learning Test (B-SVELT Sum), B-SVELT Recall, Word Fluency Test (WF), Digit Symbol Substitution Test (DSS), and Trail Making Test A and B. Individual and global neurocognitive function scores were used for analyses. Propensity matching techniques and survey generalized linear regression models were used to compare SRMD of MCI/dementia with demographic, psychological, and cardiovascular risk matched controls. Complex survey design methods were applied. Results: There were 121 cases of SRMD of MCI/dementia and 472 propensity matched controls. At baseline, compared to matched controls, cases showed no differences in neurocognitive function (p > 0.05). At SOL-INCA visit 2, cases had poorer scores in global neurocognitive function (p < 0.05), B-SEVLT Sum, B-SEVLT Recall, WF, DSS, and Trail A (p < 0.01). Conclusion: Observed differences in neurocognitive test scores between SRMD of MCI/dementia cases and matched controls were present at visit 2, but not at baseline in middle-aged and older Hispanic/Latino adults. These findings present initial evidence of the potential utility of SRMD of MCI/dementia in epidemiologic studies, where obtaining confirmation of diagnosis may not be feasible.
KW - Cognition
KW - Hispanic
KW - Latino
KW - dementia
KW - mild cognitive impairment
KW - neurocognition
UR - http://www.scopus.com/inward/record.url?scp=85133704134&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85133704134&partnerID=8YFLogxK
U2 - 10.3233/JAD-215060
DO - 10.3233/JAD-215060
M3 - Article
C2 - 35599477
AN - SCOPUS:85133704134
SN - 1387-2877
VL - 88
SP - 45
EP - 55
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 1
ER -
