TY - GEN
T1 - Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects
AU - Persak, Steven C.
AU - Sin, Sanghun
AU - Arens, Raanan
AU - Wootton, David M.
PY - 2010
Y1 - 2010
N2 - Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and - 124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.
AB - Three-dimensional (3D) analysis of the deforming airway during tidal breathing has not been performed in children with obstructive sleep apnea. We used volume-gated magnetic resonance images to segment, surface, and volume mesh the airway of one child with obstructive sleep apnea syndrome (OSAS) and one control. A computational fluid dynamics (CFD) study was performed on each airway at flow rates corresponding to 10 time points of a respiratory cycle extracted from flow data averaged over 12 consecutive breathing cycles. 3D CFD analysis showed the minimum inspiratory pressure for the OSAS subject was -250.76 Pa and - 124.24 Pa for the control. Gated MRI images depicted an overall 47% decrease in airway volume over the inspiratory cycle for the OSAS subject while the control experienced no collapse. Pressure distribution corrected for nasal resistance and turbulence kinetic energy data suggest airway collapsibility in the OSAS is a function of pharyngeal resistance and fluid and tissue mechanics rather than entirely nasal resistance.
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U2 - 10.1109/NEBC.2010.5458124
DO - 10.1109/NEBC.2010.5458124
M3 - Conference contribution
AN - SCOPUS:77953076036
SN - 9781424468799
T3 - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
BT - Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010
T2 - 36th Annual Northeast Bioengineering Conference, NEBEC 2010
Y2 - 26 March 2010 through 28 March 2010
ER -