Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues

Zeqi Huang; Michael J. Fasco; Simon Spivack; Laurence S. Kaminsky

Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues

Zeqi Huang, Michael J. Fasco, Simon Spivack, Laurence S. Kaminsky

Research output: Contribution to journal › Article › peer-review

Abstract

Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

Original language	English (US)
Pages (from-to)	2589-2592
Number of pages	4
Journal	Cancer research
Volume	57
Issue number	13
State	Published - Jul 1 1997
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues",

abstract = "Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.",

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year = "1997",

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AU - Huang, Zeqi

AU - Fasco, Michael J.

AU - Spivack, Simon

AU - Kaminsky, Laurence S.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

AB - Allelic variants of the CYP2D6 gene, a member of the cytochrome P450 gene superfamily, have been implicated in susceptibility to lung carcinogenesis. Human breast CYP2D6 and CYP2D7P (from a pseudogene) mRNAs were previously reported to be expressed as a series of splice variants. In this study, the expression of full-length and splice variants of these mRNAs in human lung tissue and tumors are reported for the first time and are compared in order to probe the potential for differential CYP2D6 regulation in lung normal tissue and tumors. The splice variant profiles differed within the same individual, but no consistent differences were detected.

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SN - 0008-5472

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JF - Cancer research

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ER -

Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues

Abstract

ASJC Scopus subject areas

UN SDGs

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