TY - JOUR
T1 - Comparison of the antitussive effects of codeine and the GABA-agonist baclofen
AU - Dicpinigaitis, Peter V.
AU - Dobkin, Jay B.
AU - Rauf, Khalid
PY - 1997
Y1 - 1997
N2 - γ-Aminobutyric acid (GABA) is an inhibitory transmitter of the central nervous system that also exists in peripheral tissues, including the lung. The GABA-agonist baclofen has been shown, in animal studies, to inhibit cough via a central mechanism. We have recently demonstrated the antitussive activity of a 14-day course oflow-dose oral baclofen in normal subjects. In the present study, we evaluated a standard cough suppressant, codeine, and compared its antitussive effect with that of a single dose of baclofen. 10 healthy, adult volunteers who had previously participated in a study evaluating the antitussive effect of a 14-day course of baclofen, underwent capsaicin cough challenge on three occasions, 2 hours after the ingestion of codeine (30 mg), baclofen (40 mg) or placebo, which were dispensed in a randomised, double-blind manner. During each study, the concentration of capsaicin inducing 5 or more coughs (C5) was determined. Significant suppression of cough was achieved by codeine (p = 0.021). Although a single dose of baclofen demonstrated cough suppression in some individuals, its effect was not significant for the study group as a whole (p = 0.066). The change in cough threshold from baseline (ΔlogC5) produced by single doses of codeine and baclofen were not significantly different p = 0.434). In light of our previous study that demonstrated the significant antitussive effect of a 14-day course of low-dose baclofen, the inability of a single, large dose of baclofen to suppress cough in the current study suggests the need for multiple administrations to achieve the optimal inhibitory effect of this agent.
AB - γ-Aminobutyric acid (GABA) is an inhibitory transmitter of the central nervous system that also exists in peripheral tissues, including the lung. The GABA-agonist baclofen has been shown, in animal studies, to inhibit cough via a central mechanism. We have recently demonstrated the antitussive activity of a 14-day course oflow-dose oral baclofen in normal subjects. In the present study, we evaluated a standard cough suppressant, codeine, and compared its antitussive effect with that of a single dose of baclofen. 10 healthy, adult volunteers who had previously participated in a study evaluating the antitussive effect of a 14-day course of baclofen, underwent capsaicin cough challenge on three occasions, 2 hours after the ingestion of codeine (30 mg), baclofen (40 mg) or placebo, which were dispensed in a randomised, double-blind manner. During each study, the concentration of capsaicin inducing 5 or more coughs (C5) was determined. Significant suppression of cough was achieved by codeine (p = 0.021). Although a single dose of baclofen demonstrated cough suppression in some individuals, its effect was not significant for the study group as a whole (p = 0.066). The change in cough threshold from baseline (ΔlogC5) produced by single doses of codeine and baclofen were not significantly different p = 0.434). In light of our previous study that demonstrated the significant antitussive effect of a 14-day course of low-dose baclofen, the inability of a single, large dose of baclofen to suppress cough in the current study suggests the need for multiple administrations to achieve the optimal inhibitory effect of this agent.
UR - http://www.scopus.com/inward/record.url?scp=0030725801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030725801&partnerID=8YFLogxK
U2 - 10.2165/00044011-199714040-00012
DO - 10.2165/00044011-199714040-00012
M3 - Article
AN - SCOPUS:0030725801
SN - 1173-2563
VL - 14
SP - 326
EP - 329
JO - Clinical Drug Investigation
JF - Clinical Drug Investigation
IS - 4
ER -