TY - JOUR
T1 - Comparison of hematological alterations and markers of B-cell activation in workers exposed to benzene, formaldehyde and trichloroethylene
AU - Bassig, Bryan A.
AU - Zhang, Luoping
AU - Vermeulen, Roel
AU - Tang, Xiaojiang
AU - Li, Guilan
AU - Hu, Wei
AU - Guo, Weihong
AU - Purdue, Mark P.
AU - Yin, Songnian
AU - Rappaport, Stephen M.
AU - Shen, Min
AU - Ji, Zhiying
AU - Qiu, Chuangyi
AU - Ge, Yichen
AU - Hosgood, H. Dean
AU - Reiss, Boris
AU - Wu, Banghua
AU - Xie, Yuxuan
AU - Li, Laiyu
AU - Yue, Fei
AU - Freeman, Laura E.Beane
AU - Blair, Aaron
AU - Hayes, Richard B.
AU - Huang, Hanlin
AU - Smith, Martyn T.
AU - Rothman, Nathaniel
AU - Lan, Qing
N1 - Publisher Copyright:
© The Author 2016. Published by Oxford University Press 2016.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Benzene, formaldehyde (FA) and trichloroethylene (TCE) are ubiquitous chemicals in workplaces and the general environment. Benzene is an established myeloid leukemogen and probable lymphomagen. FA is classified as a myeloid leukemogen but has not been associated with non-Hodgkin lymphoma (NHL), whereas TCE has been associated with NHL but not myeloid leukemia. Epidemiologic associations between FA and myeloid leukemia, and between benzene, TCE and NHL are, however, still debated. Previously, we showed that these chemicals are associated with hematotoxicity in cross-sectional studies of factory workers in China, which included extensive personal monitoring and biological sample collection. Here, we compare and contrast patterns of hematotoxicity, monosomy 7 in myeloid progenitor cells (MPCs), and B-cell activation biomarkers across these studies to further evaluate possible mechanisms of action and consistency of effects with observed hematologic cancer risks. Workers exposed to benzene or FA, but not TCE, showed declines in cell types derived from MPCs, including granulocytes and platelets. Alterations in lymphoid cell types, including B cells and CD4+ T cells, and B-cell activation markers were apparent in workers exposed to benzene or TCE. Given that alterations in myeloid and lymphoid cell types are associated with hematological malignancies, our data provide biologic insight into the epidemiological evidence linking benzene and FA exposure with myeloid leukemia risk, and TCE and benzene exposure with NHL risk.
AB - Benzene, formaldehyde (FA) and trichloroethylene (TCE) are ubiquitous chemicals in workplaces and the general environment. Benzene is an established myeloid leukemogen and probable lymphomagen. FA is classified as a myeloid leukemogen but has not been associated with non-Hodgkin lymphoma (NHL), whereas TCE has been associated with NHL but not myeloid leukemia. Epidemiologic associations between FA and myeloid leukemia, and between benzene, TCE and NHL are, however, still debated. Previously, we showed that these chemicals are associated with hematotoxicity in cross-sectional studies of factory workers in China, which included extensive personal monitoring and biological sample collection. Here, we compare and contrast patterns of hematotoxicity, monosomy 7 in myeloid progenitor cells (MPCs), and B-cell activation biomarkers across these studies to further evaluate possible mechanisms of action and consistency of effects with observed hematologic cancer risks. Workers exposed to benzene or FA, but not TCE, showed declines in cell types derived from MPCs, including granulocytes and platelets. Alterations in lymphoid cell types, including B cells and CD4+ T cells, and B-cell activation markers were apparent in workers exposed to benzene or TCE. Given that alterations in myeloid and lymphoid cell types are associated with hematological malignancies, our data provide biologic insight into the epidemiological evidence linking benzene and FA exposure with myeloid leukemia risk, and TCE and benzene exposure with NHL risk.
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U2 - 10.1093/carcin/bgw053
DO - 10.1093/carcin/bgw053
M3 - Article
C2 - 27207665
AN - SCOPUS:84978761709
SN - 0143-3334
VL - 37
SP - 692
EP - 700
JO - Carcinogenesis
JF - Carcinogenesis
IS - 7
ER -