Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Tobias Rheude; Giuliano Costa; Flavio Luciano Ribichini; Thomas Pilgrim; Ignacio J. Amat-Santos; Ole De Backer; Won Keun Kim; Henrique Barbosa Ribeiro; Francesco Saia; Matjaz Bunc; Didier Tchétché; Philippe Garot; Darren Mylotte; Francesco Burzotta; Yusuke Watanabe; Francesco Bedogni; Tullio Tesorio; Marco Tocci; Anna Franzone; Roberto Valvo; Mikko Savontaus; Hendrik Wienemann; Italo Porto; Caterina Gandolfo; Alessandro Iadanza; Alessandro S. Bortone; Markus Mach; Azeem Latib; Luigi Biasco; Maurizio Taramasso; Marco Zimarino; Daijiro Tomii; Philippe Nuyens; Lars Sondergaard; Sergio F. Camara; Tullio Palmerini; Mateusz Orzalkiewicz; Klemen Steblovnik; Bastien Degrelle; Alexandre Gautier; Paolo Alberto Del Sole; Andrea Mainardi; Michele Pighi; Mattia Lunardi; Hideyuki Kawashima; Enrico Criscione; Vincenzo Cesario; Fausto Biancari; Federico Zanin; Giovanni Esposito; Matti Adam; Eberhard Grube; Stephan Baldus; Vincenzo De Marzo; Elisa Piredda; Stefano Cannata; Fortunato Iacovelli; Martin Andreas; Valentina Frittitta; Elena Dipietro; Claudia Reddavid; Orazio Strazzieri; Silvia Motta; Domenico Angellotti; Carmelo Sgroi; Erion Xhepa; Faraj Kargoli; Corrado Tamburino; Michael Joner; Marco Barbanti

doi:10.4244/EIJ-D-23-00186

Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

Tobias Rheude, Giuliano Costa, Flavio Luciano Ribichini, Thomas Pilgrim, Ignacio J. Amat-Santos, Ole De Backer, Won Keun Kim, Henrique Barbosa Ribeiro, Francesco Saia, Matjaz Bunc, Didier Tchétché, Philippe Garot, Darren Mylotte, Francesco Burzotta, Yusuke Watanabe, Francesco Bedogni, Tullio Tesorio, Marco Tocci, Anna Franzone, Roberto ValvoMikko Savontaus, Hendrik Wienemann, Italo Porto, Caterina Gandolfo, Alessandro Iadanza, Alessandro S. Bortone, Markus Mach, Azeem Latib, Luigi Biasco, Maurizio Taramasso, Marco Zimarino, Daijiro Tomii, Philippe Nuyens, Lars Sondergaard, Sergio F. Camara, Tullio Palmerini, Mateusz Orzalkiewicz, Klemen Steblovnik, Bastien Degrelle, Alexandre Gautier, Paolo Alberto Del Sole, Andrea Mainardi, Michele Pighi, Mattia Lunardi, Hideyuki Kawashima, Enrico Criscione, Vincenzo Cesario, Fausto Biancari, Federico Zanin, Giovanni Esposito, Matti Adam, Eberhard Grube, Stephan Baldus, Vincenzo De Marzo, Elisa Piredda, Stefano Cannata, Fortunato Iacovelli, Martin Andreas, Valentina Frittitta, Elena Dipietro, Claudia Reddavid, Orazio Strazzieri, Silvia Motta, Domenico Angellotti, Carmelo Sgroi, Erion Xhepa, Faraj Kargoli, Corrado Tamburino, Michael Joner, Marco Barbanti

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

Original language	English (US)
Pages (from-to)	589-599
Number of pages	11
Journal	EuroIntervention
Volume	19
Issue number	7
DOIs	https://doi.org/10.4244/EIJ-D-23-00186
State	Published - 2023
Externally published	Yes

Keywords

• TAVI
•aortic stenosis
•coronary artery disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.4244/EIJ-D-23-00186

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Rheude, T., Costa, G., Ribichini, F. L., Pilgrim, T., Amat-Santos, I. J., De Backer, O., Kim, W. K., Ribeiro, H. B., Saia, F., Bunc, M., Tchétché, D., Garot, P., Mylotte, D., Burzotta, F., Watanabe, Y., Bedogni, F., Tesorio, T., Tocci, M., Franzone, A., ... Barbanti, M. (2023). Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation. EuroIntervention, 19(7), 589-599. https://doi.org/10.4244/EIJ-D-23-00186

Rheude, T, Costa, G, Ribichini, FL, Pilgrim, T, Amat-Santos, IJ, De Backer, O, Kim, WK, Ribeiro, HB, Saia, F, Bunc, M, Tchétché, D, Garot, P, Mylotte, D, Burzotta, F, Watanabe, Y, Bedogni, F, Tesorio, T, Tocci, M, Franzone, A, Valvo, R, Savontaus, M, Wienemann, H, Porto, I, Gandolfo, C, Iadanza, A, Bortone, AS, Mach, M, Latib, A, Biasco, L, Taramasso, M, Zimarino, M, Tomii, D, Nuyens, P, Sondergaard, L, Camara, SF, Palmerini, T, Orzalkiewicz, M, Steblovnik, K, Degrelle, B, Gautier, A, Del Sole, PA, Mainardi, A, Pighi, M, Lunardi, M, Kawashima, H, Criscione, E, Cesario, V, Biancari, F, Zanin, F, Esposito, G, Adam, M, Grube, E, Baldus, S, De Marzo, V, Piredda, E, Cannata, S, Iacovelli, F, Andreas, M, Frittitta, V, Dipietro, E, Reddavid, C, Strazzieri, O, Motta, S, Angellotti, D, Sgroi, C, Xhepa, E, Kargoli, F, Tamburino, C, Joner, M & Barbanti, M 2023, 'Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation', EuroIntervention, vol. 19, no. 7, pp. 589-599. https://doi.org/10.4244/EIJ-D-23-00186

@article{991f9aac631246bdbc64cf73cff11ef4,

title = "Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation",

abstract = "Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.",

keywords = "• TAVI, •aortic stenosis, •coronary artery disease",

author = "Tobias Rheude and Giuliano Costa and Ribichini, {Flavio Luciano} and Thomas Pilgrim and Amat-Santos, {Ignacio J.} and {De Backer}, Ole and Kim, {Won Keun} and Ribeiro, {Henrique Barbosa} and Francesco Saia and Matjaz Bunc and Didier Tch{\'e}tch{\'e} and Philippe Garot and Darren Mylotte and Francesco Burzotta and Yusuke Watanabe and Francesco Bedogni and Tullio Tesorio and Marco Tocci and Anna Franzone and Roberto Valvo and Mikko Savontaus and Hendrik Wienemann and Italo Porto and Caterina Gandolfo and Alessandro Iadanza and Bortone, {Alessandro S.} and Markus Mach and Azeem Latib and Luigi Biasco and Maurizio Taramasso and Marco Zimarino and Daijiro Tomii and Philippe Nuyens and Lars Sondergaard and Camara, {Sergio F.} and Tullio Palmerini and Mateusz Orzalkiewicz and Klemen Steblovnik and Bastien Degrelle and Alexandre Gautier and {Del Sole}, {Paolo Alberto} and Andrea Mainardi and Michele Pighi and Mattia Lunardi and Hideyuki Kawashima and Enrico Criscione and Vincenzo Cesario and Fausto Biancari and Federico Zanin and Giovanni Esposito and Matti Adam and Eberhard Grube and Stephan Baldus and {De Marzo}, Vincenzo and Elisa Piredda and Stefano Cannata and Fortunato Iacovelli and Martin Andreas and Valentina Frittitta and Elena Dipietro and Claudia Reddavid and Orazio Strazzieri and Silvia Motta and Domenico Angellotti and Carmelo Sgroi and Erion Xhepa and Faraj Kargoli and Corrado Tamburino and Michael Joner and Marco Barbanti",

year = "2023",

doi = "10.4244/EIJ-D-23-00186",

language = "English (US)",

volume = "19",

pages = "589--599",

journal = "EuroIntervention",

issn = "1774-024X",

publisher = "EuroPCR",

number = "7",

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TY - JOUR

T1 - Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

AU - Rheude, Tobias

AU - Costa, Giuliano

AU - Ribichini, Flavio Luciano

AU - Pilgrim, Thomas

AU - Amat-Santos, Ignacio J.

AU - De Backer, Ole

AU - Kim, Won Keun

AU - Ribeiro, Henrique Barbosa

AU - Saia, Francesco

AU - Bunc, Matjaz

AU - Tchétché, Didier

AU - Garot, Philippe

AU - Mylotte, Darren

AU - Burzotta, Francesco

AU - Watanabe, Yusuke

AU - Bedogni, Francesco

AU - Tesorio, Tullio

AU - Tocci, Marco

AU - Franzone, Anna

AU - Valvo, Roberto

AU - Savontaus, Mikko

AU - Wienemann, Hendrik

AU - Porto, Italo

AU - Gandolfo, Caterina

AU - Iadanza, Alessandro

AU - Bortone, Alessandro S.

AU - Mach, Markus

AU - Latib, Azeem

AU - Biasco, Luigi

AU - Taramasso, Maurizio

AU - Zimarino, Marco

AU - Tomii, Daijiro

AU - Nuyens, Philippe

AU - Sondergaard, Lars

AU - Camara, Sergio F.

AU - Palmerini, Tullio

AU - Orzalkiewicz, Mateusz

AU - Steblovnik, Klemen

AU - Degrelle, Bastien

AU - Gautier, Alexandre

AU - Del Sole, Paolo Alberto

AU - Mainardi, Andrea

AU - Pighi, Michele

AU - Lunardi, Mattia

AU - Kawashima, Hideyuki

AU - Criscione, Enrico

AU - Cesario, Vincenzo

AU - Biancari, Fausto

AU - Zanin, Federico

AU - Esposito, Giovanni

AU - Adam, Matti

AU - Grube, Eberhard

AU - Baldus, Stephan

AU - De Marzo, Vincenzo

AU - Piredda, Elisa

AU - Cannata, Stefano

AU - Iacovelli, Fortunato

AU - Andreas, Martin

AU - Frittitta, Valentina

AU - Dipietro, Elena

AU - Reddavid, Claudia

AU - Strazzieri, Orazio

AU - Motta, Silvia

AU - Angellotti, Domenico

AU - Sgroi, Carmelo

AU - Xhepa, Erion

AU - Kargoli, Faraj

AU - Tamburino, Corrado

AU - Joner, Michael

AU - Barbanti, Marco

PY - 2023

Y1 - 2023

N2 - Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

AB - Background: The optimal timing to perform percutaneous coronary interventions (PCI) in transcatheter aortic valve implantation (TAVI) patients remains unknown. Aims: We sought to compare different PCI timing strategies in TAVI patients. Methods: The REVASC-TAVI registry is an international registry including patients undergoing TAVI with significant, stable coronary artery disease (CAD) at preprocedural workup. In this analysis, patients scheduled to undergo PCI before, after or concomitantly with TAVI were included. The main endpoints were all-cause death and a composite of all-cause death, stroke, myocardial infarction (MI) or rehospitalisation for congestive heart failure (CHF) at 2 years. Outcomes were adjusted using the inverse probability treatment weighting (IPTW) method. Results: A total of 1,603 patients were included. PCI was performed before, after or concomitantly with TAVI in 65.6% (n=1,052), 9.8% (n=157) or 24.6% (n=394), respectively. At 2 years, all-cause death was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (6.8% vs 20.1% vs 20.6%; p<0.001). Likewise, the composite endpoint was significantly lower in patients undergoing PCI after TAVI as compared with PCI before or concomitantly with TAVI (17.4% vs 30.4% vs 30.0%; p=0.003). Results were confirmed at landmark analyses considering events from 0 to 30 days and from 31 to 720 days. Conclusions: In patients with severe aortic stenosis and stable coronary artery disease scheduled for TAVI, performance of PCI after TAVI seems to be associated with improved 2-year clinical outcomes compared with other revascularisation timing strategies. These results need to be confirmed in randomised clinical trials.

KW - • TAVI

KW - •aortic stenosis

KW - •coronary artery disease

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UR - http://www.scopus.com/inward/citedby.url?scp=85169139358&partnerID=8YFLogxK

U2 - 10.4244/EIJ-D-23-00186

DO - 10.4244/EIJ-D-23-00186

M3 - Article

C2 - 37436190

AN - SCOPUS:85169139358

SN - 1774-024X

VL - 19

SP - 589

EP - 599

JO - EuroIntervention

JF - EuroIntervention

IS - 7

ER -

Comparison of different percutaneous revascularisation timing strategies in patients undergoing transcatheter aortic valve implantation

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