Comparison of cardiopulmonary exercise testing variables in COPD patients with and without coronary artery disease

Wilawan Thirapatarapong, Hilary F. Armstrong, Matthew N. Bartels

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background: Coronary artery disease (CAD) is a common concomitant condition and an important cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). Since COPD and CAD can both independently cause reduced exercise capacity, it is reasonable to hypothesize that the combination of these diseases may compound the abnormalities observed during cardiopulmonary exercise testing (CPET). However, little is known about the impact of CAD on the CPET response in COPD patients. The aim of this study is to compare exercise capacity and gas exchange variables in COPD patients with and without CAD. Methods: Fifty-four COPD subjects without CAD (COPDnoCAD) were matched to 54 COPD subjects diagnosed with CAD (COPD/CAD) according to age, gender, body mass index and severity of COPD. All subjects underwent resting pulmonary function and symptom-limited CPET. Results: Comparing COPDnoCAD patients with COPD/CAD patients revealed that exercise capacity, as measured by % peak oxygen consumption (42±16% vs 53±19%, p=0.002) and % peak wattage (23±13% vs 32±16%, p=0.001), was significantly lower in COPD/CAD. Ventilatory response, as measured by VE/VCO2 nadir (36±9 vs 32±5, p=0.001), was significantly higher in COPD/CAD, with % peak VO2 and VE/VCO2 nadir correlating to % FEV1 and inversely correlating with %DLCO. Conclusion: COPD patients with CAD have significantly impaired CPET responses with lower exercise capacity and impaired gas exchange compared to COPD patients without CAD. These findings may affect the clinical interpretation of CPET data in COPD patients who have concomitant CAD.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalHeart and Lung: Journal of Acute and Critical Care
Issue number2
StatePublished - Mar 2014
Externally publishedYes


  • COPD
  • Coronary artery disease
  • Exercise capacity
  • Ventilatory efficiency

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Comparison of cardiopulmonary exercise testing variables in COPD patients with and without coronary artery disease'. Together they form a unique fingerprint.

Cite this