Comment on 5-HT and mechanisms of defence

Scott Wetzler, Gregory M. Asnis, Herman M. Van Praag

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The paper by Deakin and Graeff is a thought-provoking tour-de-force. They propose a comprehensive theory about serotonin (5-hydroxytryptamine; 5-HT) and anxiety, covering much of the same literature which we previously reviewed (Kahn et al., 1988a). We certainly agree that there seems to be an association between 5-HT function and anxiety, but we take issue with several important aspects of Deakin and Graeff's hypothesis. We limit our comments to their discussion of anxiety and panic.

Original languageEnglish (US)
Pages (from-to)332-333
Number of pages2
JournalJournal of Psychopharmacology
Issue number4
StatePublished - Jul 1991

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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