Combining theranostic/particle therapy with immunotherapy for the treatment of GU malignancies

Karin A. Skalina; Beata Małachowska; Kunal K. Sindhu; Marcher Thompson; Anthony D. Nehlsen; Lucas Resende Salgado; Zachary Dovey; Shaakir Hasan; Chandan Guha; Justin Tang

doi:10.1002/bco2.316

Combining theranostic/particle therapy with immunotherapy for the treatment of GU malignancies

Karin A. Skalina, Beata Małachowska, Kunal K. Sindhu, Marcher Thompson, Anthony D. Nehlsen, Lucas Resende Salgado, Zachary Dovey, Shaakir Hasan, Chandan Guha, Justin Tang

Radiation Oncology

Research output: Contribution to journal › Review article › peer-review

Abstract

Particle therapy and radiopharmaceuticals are emerging fields in the treatment of genitourinary cancers. With these novel techniques and the ever-growing immunotherapy options, the combinations of these therapies have the potential to improve current cancer cure rates. However, the most effective sequence and combination of these therapies is unknown and is a question that is actively being explored in multiple ongoing clinical trials. Here, we review the immunological effects of particle therapy and the available radiopharmaceuticals and discuss how best to combine these therapies.

Original language	English (US)
Pages (from-to)	334-344
Number of pages	11
Journal	BJUI Compass
Volume	5
Issue number	3
DOIs	https://doi.org/10.1002/bco2.316
State	Published - Mar 2024

Keywords

abscopal effect
cancers
genitourinary
immunotherapy
particle therapy
theranostics

ASJC Scopus subject areas

Urology
Oncology
Surgery
Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/bco2.316

Cite this

@article{f02fd67d32b64643ba141d9466be23f1,

title = "Combining theranostic/particle therapy with immunotherapy for the treatment of GU malignancies",

abstract = "Particle therapy and radiopharmaceuticals are emerging fields in the treatment of genitourinary cancers. With these novel techniques and the ever-growing immunotherapy options, the combinations of these therapies have the potential to improve current cancer cure rates. However, the most effective sequence and combination of these therapies is unknown and is a question that is actively being explored in multiple ongoing clinical trials. Here, we review the immunological effects of particle therapy and the available radiopharmaceuticals and discuss how best to combine these therapies.",

keywords = "abscopal effect, cancers, genitourinary, immunotherapy, particle therapy, theranostics",

author = "Skalina, {Karin A.} and Beata Ma{\l}achowska and Sindhu, {Kunal K.} and Marcher Thompson and Nehlsen, {Anthony D.} and Salgado, {Lucas Resende} and Zachary Dovey and Shaakir Hasan and Chandan Guha and Justin Tang",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.",

year = "2024",

month = mar,

doi = "10.1002/bco2.316",

language = "English (US)",

volume = "5",

pages = "334--344",

journal = "BJUI Compass",

issn = "2688-4526",

number = "3",

}

TY - JOUR

T1 - Combining theranostic/particle therapy with immunotherapy for the treatment of GU malignancies

AU - Skalina, Karin A.

AU - Małachowska, Beata

AU - Sindhu, Kunal K.

AU - Thompson, Marcher

AU - Nehlsen, Anthony D.

AU - Salgado, Lucas Resende

AU - Dovey, Zachary

AU - Hasan, Shaakir

AU - Guha, Chandan

AU - Tang, Justin

PY - 2024/3

Y1 - 2024/3

N2 - Particle therapy and radiopharmaceuticals are emerging fields in the treatment of genitourinary cancers. With these novel techniques and the ever-growing immunotherapy options, the combinations of these therapies have the potential to improve current cancer cure rates. However, the most effective sequence and combination of these therapies is unknown and is a question that is actively being explored in multiple ongoing clinical trials. Here, we review the immunological effects of particle therapy and the available radiopharmaceuticals and discuss how best to combine these therapies.

AB - Particle therapy and radiopharmaceuticals are emerging fields in the treatment of genitourinary cancers. With these novel techniques and the ever-growing immunotherapy options, the combinations of these therapies have the potential to improve current cancer cure rates. However, the most effective sequence and combination of these therapies is unknown and is a question that is actively being explored in multiple ongoing clinical trials. Here, we review the immunological effects of particle therapy and the available radiopharmaceuticals and discuss how best to combine these therapies.

KW - abscopal effect

KW - cancers

KW - genitourinary

KW - immunotherapy

KW - particle therapy

KW - theranostics

UR - http://www.scopus.com/inward/record.url?scp=85179313103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85179313103&partnerID=8YFLogxK

U2 - 10.1002/bco2.316

DO - 10.1002/bco2.316

M3 - Review article

AN - SCOPUS:85179313103

SN - 2688-4526

VL - 5

SP - 334

EP - 344

JO - BJUI Compass

JF - BJUI Compass

IS - 3

ER -

Combining theranostic/particle therapy with immunotherapy for the treatment of GU malignancies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this